Our editorial/commentary: "Fragile skin may benefit from decoration" sciencedirect.com/science/articl e/pii/S3117387X2600162X just appeared in the September issue of the Molecular Therapy Advances! 👍

Molecular Therapy Family of Journals@moltherapy.bsky.social · last mo.

The latest issue of Molecular Therapy Advances features original research focused on a dual-AAV otoferlin gene therapy for congenital deafness, anti-CAR antibodies in patients treated with anti-BCMA CAR T cell therapy, and more. https://bit.ly/4cWWPVl

How do human large blood vessels respond to hypoxia? Paucity of evidence until large arteries & veins collected after severe lower extremity trauma reveal rapid, but transient intimal hyperplasia and adventitial angiogenesis from veins. @evborg.bsky.social @navbo.bsky.social rdcu.be/XyAQYUmiqQma

We are in Halo! Our drug screening technology for homing and tissue penetrating macrocyclic peptides based on in vivo phage display & microdialysis (www.life-science-alliance.org/content/8/5/...) & macrocyclic homing peptides for targeted drug delivery are presented. www.halo.science/profile/tero...

Tero Järvinen's profile

Tero Järvinen is a Principal Investigator at Tampere University. Expertise in Biopharmaceutics, Cardiovascular, Molecular Biology. Explore collaboration opportunities on Halo Science.

halo.science

These parents set up biotechnology companies, hoping to cure their children's illnesses go.nature.com/4o0hV92

Meet the biotech-company founders driven by their child’s rare disease

For some parents, finding a cure for their child’s illness is the ultimate motivation to start a company.

go.nature.com

Dr Afsaneh Ehsandoost come to my lab as a EDUFI-student. Happy to announce the publication of the chitosan scaffolds she created: a novel approach to mimicking native skin architecture doi.org/10.1088/1748... via @ioppublishing.bsky.social

We have developed a new way of performing in vivo phage display screens by introducing microdialysis catheter into the in vivo screen to capture the macrocyclic homing and tissue penetrating peptides for efficient drug delivery www.life-science-alliance.org/content/8/5/... @lsajournal.org

Macrocyclic vascular homing peptide CAR not only works as drug delivery vehicle, but as a drug by itself; CAR homes to skin wound, binds to syndecan 4, which activates cytohesin 2 to activate small GTPase Arf6 to accelerate skin wound closure. www.nature.com/articles/s41... @natcomms.nature.com

In 2002, I watched hundreds of surgeons jump out of their seats to blast a speaker. @nejm.org Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes | New England Journal of Medicine www.nejm.org/doi/full/10....

Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes | NEJM

In this trial of arthroscopic partial meniscectomy for degenerative medial meniscal tear in adults, participant-reported and radiologic outcomes over 10 years of follow-up suggested no benefit and ...

nejm.org

Three must-read articles that sparked major news coverage in April.

In the FIDELITY trial of arthroscopic partial meniscectomy for degenerative medial meniscal tear in adults, participant-reported and radiologic outcomes over 10 years of follow-up suggested no benefit and possible harm from the procedure. Full trial results: https://nej.md/48Pkwww #Orthopedics

MedicalResearch.com now interview with Teppo Järvinen, Professor of Orthopaedics and Traumatology, University of Helsinki and HUS. You can find more information about the interview here: medicalresearch.com/nejm-arthros...

NEJM: Arthroscopic Partial Meniscectomy Provided No Benefit Over Placebo Surgery and May Worsen Longterm Outcomes

This study contributes to the concept of medical reversal, where widely used treatments are shown to be ineffective or harmful when tested rigorously.

medicalresearch.com

Hot off the press! We demonstrate in Cancer Res that the αv integrin- and neuropilin-1 (NRP-1)-dual targeting iRGD peptide (in phase II clinical trials) reverses some of these tumor microenvironment features by inhibiting TGF-β activation in the tumor: aacrjournals.org/cancerres/ar...

"Fragile skin may benefit from decoration" - our commentary (to Nyström-lab original article) addresses Decorin as a potential drug for the RDEB patients www.sciencedirect.com/science/arti...