Congratulations to Sampled on its new five-year VA contract supporting the Million Veteran Program! 👏 With multiple PacBio Revio systems, Sampled is bringing scalable HiFi sequencing to one of the world’s largest research programs of its kind. Read more: https://prn.to/4y5klHq

Benchmarking by Harvey et al. shows PacBio HiFi achieves higher indel & SV recall at 20x than ONT achieves at 60x+. 📊 Citing the right peer-reviewed data is key to a winning grant proposal. See how our literature library helps you write yours faster: https://bit.ly/4ycWZ3q

Featured in The Scientist: Dr. Alexander Hoischen discusses how long-read sequencing on the Revio system is helping end the rare disease diagnostic odyssey by filling the gaps left by short reads. Read the interview: bit.ly/4i3LKFl #PacBio #Revio #RareDisease #HiFiSequencing

Leveling the playing field, one long read at a time. Vega SPRQ-Nx chemistry is now shipping! Bring higher throughput, lower DNA input, shorter run times, and expanded methylation detection to your benchtop. What will you discover? Learn more: bit.ly/3TCbMoR

T2T genomics is quickly becoming less of an endpoint and more of a starting point for discovery. A new Cell issue features 13 papers on complete diploid genome assemblies across species like humans, marmosets, horses, giraffes, and more. Explore the research: bit.ly/4wAdZiw

I can't believe it's already been 5 years since I first released sandbox.bio! 🥳 To celebrate, next week we'll release one new feature every day of the week. Follow along at sandbox.bio/anniversary, or here on BlueSky.

For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]

Last call! Register for our New Technology Session: HiFi Long-Read #Bioinformatics Bootcamp. Learn to turn raw data into insights, master file formats and workflows for genomes or transcriptomes, and get on-demand lessons plus live Q&A access. Save your spot: bit.ly/4yADNx5

Big updates coming to Vega! SPRQ-Nx chemistry drops cost per Gb by 40% with 90 Gb yield, $995 run pricing, 500 ng input minimums, 2-to-4 hour run times, and 21 CFR Part 11 compliance controls. Read the full press release to explore the full specs: bit.ly/3Rxyjmd

What a great looking @pacbio.bsky.social genome!

Maribeth Latvis@maribethlatvis.bsky.social · 3mo ago

Ren Hamm debuting the Castilleja foliolosa genome! #botany2026

Though I will not make it to #Botany2026, Doug Soltis and Jacob Landis will tag-team my talk on Monday at 2:15 pm in Population Genomics (San Ignacio)!

Shelly Gaynor@shellygaynor.bsky.social · 3mo ago

I was really excited to attend #Botany2026, but sadly my cat is very sick and I decided I couldn't leave her right now. I believe @jlandisbotany.bsky.social will be giving my talk. And luckily the @soltislab.bsky.social can do the workshop without me. Really sad to miss this year!

New to HiFi sequencing? Come learn about the basics of analyzing PacBio data in our bioinformatics bootcamp featuring….me? Register now! programs.pacb.com/l/1652/2026-...

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PacBio@pacbio.bsky.social · 3mo ago

Join our New Tech Session: HiFi Long-Read Bioinformatics Bootcamp! 🧬 Build a solid foundation for analyzing PacBio HiFi data with an on-demand video playlist plus a live Q&A with PacBio experts. Master key file formats, core tools, and data processing best practices. Register today: bit.ly/4yADNx5

Registration is still open for our webinar on how SPRQ-Nx chemistry on Vega drives benchtop long-read sequencing performance up and costs down. Learn how lower DNA input, higher HiFi yield, and 21 CFR Part 11 support accelerate biopharma, microbiology, and more. Register: bit.ly/3RjPzLo

Which targeted sequencing approach is right for you? In this short video, Samantha walks through three key PacBio HiFi approaches: amplicon, hybrid capture, and PureTarget. Watch to find the best fit to simplify your strategy: bit.ly/4ffnKMe #PacBio #HiFiSequencing #Genomics

nQuack is officially a CRAN package! After a request to use nQuack as a dependency for another package, I finally upload V1 to CRAN. cran.r-project.org/web/packages...

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The new Rapid HiFi WGS Resource Bundle is now available to accelerate your time-critical genomic research. Get instant access to four essential pieces: our latest technical note, ESHG poster, application note, and blog article. Access the resources now: bit.ly/4eYvYIp #PacBio

Slowly updating my website to a lab site and having way too much fun. GEEP lab launching in Spring 2027!

Registration is open for our webinar on how SPRQ-Nx chemistry on Vega drives benchtop long-read sequencing performance up and costs down. Learn how lower DNA input, higher HiFi yield, and 21 CFR Part 11 support accelerate biopharma, microbiology, and more. Register here: bit.ly/3RjPzLo

Working on plant breeding? Excited about non-traditional genetic systems in crops and their wild relatives? We are organizing a special issue: www.frontiersin.org/research-top...

Huge congratulations to the All of Us Research Program on their historic data release! 🌍🧬 Thrilled to see HiFi sequencing contribute through 14K+ long read genomes. Through their participation, 747K+ individuals are making this possible. Details: bit.ly/4gOgSYr

A new Nature Genetics piece from @radboudumc.bsky.social outlines Near-Perfect Genome Sequencing (NPGS): a framework combining long-reads, diploid assembly, pangenomes, and AI to shift from fragmented testing to a single comprehensive genomic assay. Read more here: go.nature.com/4ey5YF0 #PacBio

Near-perfect genome sequencing in medical genetics - Nature Genetics

This Perspective introduces near-perfect genome sequencing, which encompasses diploid genome assembly, pangenome references and artificial intelligence-driven variant interpretation, and proposes a ro...

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The FDA's new draft guidance on genome editing safety highlights why detecting large indels and chromosomal abnormalities is critical, where short-reads fall short. HiFi sequencing offers >99.9% accuracy to characterize all editing outcomes. Learn more: bit.ly/49ZpV4S

Margres et al. investigated snake venom expression divergence in island-mainland rattlesnakes, showing that rapid adaptation in the island population occurred through the co-option and truncation of the ontogenetic venom shift. 🔗 doi.org/10.1093/gbe/evag131 📷 Michael P. Hogan #genome #evolution

From sample prep to analysis, the #PacBio HiFi workflow is easy and delivers 99.9% accuracy. 🧬 Get our free HiFi Starter Kit: all the guides, checklists, and decision trees needed to map out your research. Download the kit to plan your next experiment: bit.ly/41ePDxQ #TheresHiFiForThat

How much DNA input do you actually need for HiFi sequencing? We are answering question 5 in our Top 5 Questions series, including how labs can get started with lower DNA input requirements using workflows like Ampli-Fi. Full video here: bit.ly/4cBxnVp #TheresHiFiForThat #PacBio #HiFisequencing

SPRQ-Nx chemistry is now shipping worldwide, bringing sub-$300 HiFi genomes to the Revio platform! This global rollout cuts sequencing costs by 30%, making it easier than ever to scale high-throughput workflows Full press release here: bit.ly/49HwmcL #SPRQNx #PacBio #HiFisequencing #Revio

Excited to share that I will be joining Florida State University as an Assistant Professor starting in January 2027! I’m thrilled to build my lab at FSU in the Ecology & Evolution Division within the Department of Biological Science — stay tuned! A huge thank you to my village for all the support!

Long-read sequencing has come a long way. With SPRQ-Nx chemistry, PacBio has driven costs down to $6 per Gb. New to HiFi? Download our Starter Kit to get a technology guide, decision tree, and planning checklist. Get the kit here: bit.ly/41ePDxQ #TheresHiFiForThat #PacBio #HiFisequencing

How do you navigate the traditional trade-offs in sequencing? Today, you can capture genetic variation and native methylation simultaneously in a single run without extra prep. Check out our blog to see how HiFi sequencing has rewritten the old rules: bit.ly/3RijsLN #PacBio

If your Nanopore- based long-read data is full of noise, is it actually useful? Next in our Top 5: Why choose #PacBio HiFi over other long-read methods? The answer is 99.9% accuracy. No GC bias, no repetitive region dropouts, and reliable results for every species. Watch: bit.ly/4cBxnVp