If you're interested in hearing about lymph node metastasis, tumor evolution, T cells, and immunotherapy, check out this @theNCI forum tomorrow, featuring Mary Jo Turk, @naxerova, and Alexander Huang. events.cancer.gov/dcb/tdln #TDLNForums

Lymph node metastasis is almost always synonymous with cancer progression, but in this fantastic study from @ubellackerlab.bsky.social, they reveal that it also imparts a key metabolic vulnerability: FSP1 dependency. Congrats Jess and @mariopalma.bsky.social!

Ubellacker Lab@ubellackerlab.bsky.social · 9mo ago

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Evolution Under Therapy: Resistance Mechanisms— Andrew J. Aguirre, Nathan Reticker-Flynn, Susan M. Rosenberg, and Kathleen Burkhardt will address this topic in a plenary at the AACR Special Conference on Cancer Evolution (Dec 4-6; Albuquerque). buff.ly/4ecfgxE #AACRevol25 @retickerflynn.bsky.social

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Prospects for ferroptosis therapies in cancer

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

rdcu.be

Harvard Molecular Metabolism@met-hsph.bsky.social · 12mo ago

Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out rdcu.be/eBbqV

Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com bsky.app/profile/nat...

Our lab has an opening for a new Research Assistant (LSRP) starting this Summer/Fall. If you're interested in joining a vibrant community working at the interfaces of cancer metastasis and adaptive immunity, apply here: careersearch.stanford.edu/jobs/life-sc...

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States

Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects....

careersearch.stanford.edu

Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS

Redirecting immune signaling with cytokine adaptors

Nature Communications - Cytokines are immune signaling molecules that are frequently dysregulated in disease. Here, the authors create engineered cytokine ‘adaptors,’ molecular switches...

rdcu.be

First Bluesky post! If you're interested in hearing about our work, check out this seminar in a couple weeks.

Metastasis Research Society@metastasisresearch.bsky.social · 2y ago

Calling all metastasis researchers - don't forget to join us for our next webinar on Dec 3rd as Dr. Nathan Reticker-Flynn discusses "Lymph node metastasis and the orchestration of adaptive immune responses to tumors". Sign-up today! us02web.zoom.us/webinar/regi...