Directed evolution of multimeric proteins is enabled by dual-compensatory gene duplication https://www.biorxiv.org/content/10.64898/2026.01.12.698938v1

Directed evolution of multimeric proteins is enabled by dual-compensatory gene duplication https://www.biorxiv.org/content/10.64898/2026.01.12.698938v1

Nature has a trick to evolve multimeric proteins via gene duplication. 🧬One copy compensates, the other explores.🧬 Although this has only been a theory so far. Until now: Directed evolution of multimeric proteins by dual-compensatory gene duplication. www.biorxiv.org/content/10.6...

Submitted! 🧬 New preprint dropping tomorrow. We’ve cracked a tough nut regarding evolution, and I can’t wait to show you the data. Watch this space.

Had a wonderful time presenting at @SynBioAusAsia 2025 about the discovery and developments of #seekRNA gene editing tech and how it stacks up against literature and industry standards. So grateful to have met so many like-minded scientists and keen to see where we go from here!

Every hear of Vaults? If not, read this preprint! New from the lab, exploring novel mechanisms of RNA trafficking in neurons and what they might mean for memory. Led by stellar PhD student Mason Musgrove. #RNAsky www.biorxiv.org/cgi/content/...

Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

Vaults are large ribonucleoprotein complexes of unknown function in neurons. Here, we report that the Vault-associated noncoding RNA, Vaultrc5, is highly enriched at the synapse and is required for ac...

biorxiv.org

Congrats to @taylorszyszka.bsky.social and @rezwansiddiquee.bsky.social who have been invited to Raise the Bar! 20 academics will visit 10 bars across Sydney to talk about their research, for 1 night only. 📅 Thu 3 April, 7:30 PM 📍Bank Hotel, 324 King St, Newtown 🎟️ Register: bit.ly/43Ci7n0 #RTBSYD

Really proud of the famous Taylor Szyszka for the perseverance for this project! Amazing work!

Lorne Proteins@lorneproteins.bsky.social · last yr.

Light-ning Talks #LorneProteins2025 Taylor Szyszka Engineering carbon-fixing protein cages. Carboxysomes are great, but encapsulins can assemble a uniform cage around any target tagged with a cargo peptide at C term. 42 nm across. Carboxysome mimic with encapsulin? Encapsulating rubisco.

Had such a wonderful time at #Coesb2024! Got to meet like minded synthetic biologists and learn about their successes and challenges. And huge thanks to @ARC_CoESB for an award for Outreach Excellence!

My first ever Bluesky post is a new #preprint alert! What if we could put *anything* into a protein cage? Our new in vitro encapsulin assembly system is esay to use and enables the pacakging of protein and synthetic cargo! www.biorxiv.org/content/10.1...

High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages

Cargo-filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packa...

biorxiv.org

This is a great tool to search for your community and quickly follow a bunch of people!

Bluesky Starter Pack@blueskystarterpack.com · 2y ago

blueskystarterpack.com

I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅 #sciart #blender3d #biocatalysis

Very excited to share our new pre-print! We’ve developed a new way to put any type of cargo (biological or synthetic) into protein cages! All in-vitro! This enables massively scalable in vitro packaging technology for multiple lucrative applications. www.biorxiv.org/content/10.1...

High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages

Cargo-filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packa...

biorxiv.org

Long time lurker, first time poster... announcing our latest preprint on encapsulin protein cages! We can now assemble them beautifully in vitro, without the ugly defects you get using acid/base or denaturants. This lets us put any synthetic cargo into these cages. www.biorxiv.org/content/10.1...