Excited to share our latest work ! Here, we identified the lectin CLEC7A as a sensor of aberrant IgG glycosylation, signaling through SYK to drive podocyte injury. This study is part of a broader effort in our group to understand immune-podocyte crosstalk in lupus nephritis.

ACR Journals@acr-journals.bsky.social · 4mo ago

New insights in lupus nephritis show abnormal IgG glycosylation triggers podocyte injury via CLEC7A-SYK signaling. Blocking this pathway preserved podocyte function, uncovering a potential novel therapeutic strategy for LN Arthritis & Rheumatology doi.org/10.1002/art....

Here is our latest work highlighting the role of kidney resident cells (specifically podocytes) in preventing nephritis and kidney immune complex deposition in SLE. Published online 👇 doi.org/10.1016/j.cl... Also first post on here. :)