New pre-print plug! We used snRNA-seq to lay out a rostrocaudal atlas of the mouse spinal cord across lifespan to define normative aging programs in major cell types. We compared an atlas of ALS progression in the SOD1-G93A model. Peer-reviewed version in the works. www.biorxiv.org/content/10.6...

Ho Lab enjoyed a great #ALS Network Research Summit in San Francisco!

www.biorxiv.org/content/10.1... Our preprint is posted. We highlight the sex-based differences in motor function decline in SOD1G93A mice, a model for amyotrophic lateral sclerosis (#ALS).

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosis

The transgenic SOD1G93A mouse model is the most widely used animal model of amyotrophic lateral sclerosis (ALS), a fatal disease of motor neuron degeneration. While genetic background influences onset...

biorxiv.org