Irritable bowel syndrome (IBS) affects 5–10% of people worldwide. A new Review discusses the current understanding of the pathophysiology of IBS in terms of peripheral, central, and integrated mechanisms. Read in @lancetgastrohep.bsky.social: tinyurl.com/5cankju9

🔔 Discover The Lancet Surgery & Anaesthesiology, a new journal with a sharp clinical focus, dedicated to advancing science across the full extent of #surgery, #anaesthesiology, and #perioperative specialties, across the age spectrum, and across the globe: spkl.io/633237JQbc

And you can read more about Epstein-Barr virus (EBV) and multiple sclerosis (MS) in a Rapid Review, covering new insights into how EBV might cause MS and the potential for future prevention and treatment www.thelancet.com/journals/lan...

Epstein–Barr virus and multiple sclerosis: from associations to mechanisms to potential therapies

Epstein–Barr virus, a widespread herpesvirus that establishes lifelong latency after primary infection, has emerged in serological and epidemiological studies as a strong and consistent risk factor fo...

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Our August 2026 issue is live! Including research on sacroiliac joint #bonemarrowoedema, a precision medicine tool in #Sjögrens disease, the role of #healthliteracy in #inflammatoryarthritis, plus much more! thelancet.com/journals/lanrhe/home Cover by @emma-cheng.bsky.social #Medsky #Rheumsky

🆕The glucagon and GLP-1 receptor dual agonist DD01 for metabolic dysfunction-associated steatotic liver disease and steatohepatitis (DD01-DN-02): 12-week results from a randomised, placebo-controlled, phase 2 trial www.thelancet.com/journals/lan... #LiverSky #MedSky

The glucagon and GLP-1 receptor dual agonist DD01 for metabolic dysfunction-associated steatotic liver disease and steatohepatitis (DD01-DN-02): 12-week results from a randomised, double-blind, multic...

In this prespecified 12-week primary analysis, DD01 produced rapid reductions in liver fat compared with placebo, supporting further evaluation in long-term studies.

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New - Efficacy and safety of zalfermin co-administered with semaglutide in participants with fibrosis and cirrhosis due to metabolic dysfunction-associated steatohepatitis: a phase 2 randomised controlled trial www.thelancet.com/journals/lan... #LiverSky #MedSky

Efficacy and safety of zalfermin co-administered with semaglutide in participants with fibrosis and cirrhosis due to metabolic dysfunction-associated steatohepatitis: a phase 2, dose-ranging, double-b...

In participants with metabolic dysfunction-associated steatohepatitis and clinically significant fibrosis, the combination of zalfermin 30 mg plus semaglutide 2·4 mg did not significantly increase the...

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🆕Results from RELIEVE UCCD - efficacy and safety of duvakitug in patients with Crohn's disease or ulcerative colitis UC - www.thelancet.com/journals/lan... CD - www.thelancet.com/journals/lan... #GastroSky #MedSky #IBDSky

Efficacy and safety of duvakitug in patients with ulcerative colitis (RELIEVE UCCD): a phase 2b, randomised, placebo-controlled trial

Duvakitug showed significant evidence for clinical remission versus placebo, with no safety concerns identified, in patients with moderately to severely active ulcerative colitis.

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🆕Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial www.thelancet.com/journals/lan... #GastroSky #OncSky #MedSky #AI

Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial

CADe-assisted colonoscopy did not show the absolute improvement in adenoma detection rate that was assumed in the prespecified sample-size calculation. CADx did not clearly improve lesion differentiat...

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The August 2026 issue of @lancetgastrohep.bsky.social hep.bsky.social is out now at www.thelancet.com/gastrohep! Content includes #pancreaticcancer, #IBD, eosinophilic #gastritis, #livercancer, #MASLD + more! #GastroSky #LiverSky #MedSky

🆕The role of primary care in response to the global liver disease syndemic A new @lancetgastrohep.bsky.social Commission thelancet.com/commissions-... #LiverSky #MedSky #PrimaryCare

Our July issue is now online: www.thelancet.com/journals/lan... Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #hepatitis #HBV #AMR #RSV #Streptococcus #PCV13 #STI #SARS-CoV-2 #Strongyloides #keratitis #IDSky #ClinMicro #ViroSky #OA

Ready to share your #gastroenterology and #hepatology research with millions globally? Explore our author resources for a seamless submission process, and start your publication journey with us today: hubs.li/Q04mkDC40   #GastroSky #MedSky #LiverSky

Behind every paper is a community. To every author who trusted us with their research and every peer reviewer who gave their time and expertise—thank you! Together, we are advancing the best science for better lives. Learn about our peer review process: hubs.li/Q04mkDC40

We are the world-leading journal dedicated to #gastroenterology and #hepatology research and review, ranking:   #1 for Scopus CiteScore (64·3)   #3 for Journal Impact Factor (39·1)   Explore our high impact and global reach: hubs.li/Q04k--0J0   #GastroSky #LiverSky

Join us at the WONCA Europe Conference in Paris on July 1st for the launch of the The Lancet Gastroenterology & Hepatology Commission on the role of primary care in the response to the global liver syndemic! #LiverSky #PrimaryCare #HealthCare #Medicine

🆕Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial www.thelancet.com/journals/lan... #GastroSky #MedSky

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial

The improvement of histological outcomes of eosinophilic gastritis with dupilumab in this proof-of-concept study shows type 2 inflammatory involvement in the disease and the potential value of dupilum...

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🆕 HLA-DRB1*01:03 in patients with inflammatory bowel disease: a genotype–phenotype association study www.thelancet.com/journals/lan... #IBDSky #GastroSky #MedSky

The July issue of @lancetgastrohep.bsky.social is out now at www.thelancet.com/journals/lan...! Content includes: #colorectalcancer, #viralhepatitis, #IBD, #MASLD + more... #GastroSky #MedSky #IDSky #OncSky #LiverSky

New review article From microbiomes to predictive ecosystems: challenges and opportunities in artificial intelligence-based approaches www.thelancet.com/journals/lan... #IDSky #ClinMicro #microbiome #AI #OpenAccess #OA

🆕 Research | Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial www.thelancet.com/journals/lan... #GastroSky #OncSky #rectalcancer

Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial

Non-inferiority of adjuvant chemoradiotherapy compared with cTME for 3-year locoregional recurrence could not formally be demonstrated. However, loss of equipoise hampered patient accrual, precluding ...

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I’ll be at #EASLCongress in Barcelona for @lancetgastrohep.bsky.social this week — drop me a line if you’d like to catch up! #LiverSky #MedSky #EASL2026

🆕The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729–001): a phase 1a/b trial www.thelancet.com/journals/lan... #LiverSky #MedSky #IDSky #HepSky #MicroSky

The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729–001): a phase 1a/b trial

Single and multiple doses of imdusiran were safe and well tolerated in healthy individuals and in individuals with chronic hepatitis B, supporting drug development of imdusiran as a future treatment t...

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Our May issue is now online: www.thelancet.com/journals/lan... Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #Streptococcus #PCV13 #SARS-CoV-2 #mpox #influenza #hepatitis #HBV #HDV #polio #OneHealth #IDSky #ClinMicro #OA

New - Intestinal ultrasound to detect postoperative recurrence in patients with Crohn's disease: an international, multidisciplinary, RAND/UCLA appropriateness method study www.thelancet.com/journals/lan... #GastroSky #MedSky #IBDSky

Review - Management of colorectal cancer in older adults: an expert panel recommendation to guide daily clinical practice www.thelancet.com/journals/lan... #OncSky #MedSky #GastroSky

Management of colorectal cancer in older adults: an expert panel recommendation to guide daily clinical practice

Colorectal cancer predominantly affects older adults (ie, those aged 70 years or older). Along with shifting demographic trends, the number of patients with colorectal cancer in this age group is esti...

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🆕Viewpoint - Breaking the therapeutic ceiling in inflammatory bowel disease: myth or reality? www.thelancet.com/journals/lan... #GastroSky #MedSky #IBDSky

Breaking the therapeutic ceiling in inflammatory bowel disease: myth or reality?

Despite an expanding therapeutic armamentarium, remission rates in inflammatory bowel disease (IBD) appear to plateau at 30–50% after 1 year of treatment, leading to the concept of a therapeutic ceili...

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New research article #Norovirus GII.4 serological repertoire in older adults after GII.4 ancestral variant vaccination: a post-hoc analysis of a randomised, double-blind, phase 2 trial www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #OpenAccess #OA

New personal view article Antimicrobial resistance surveillance through wastewater: methodological considerations for metagenomic approaches and public health perspectives www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #OpenAccess #OA

The May 2026 issue of The Lancet Regional Health - Americas is now available online! lnkd.in/gcRM-wYU In this issue: #OpioidPrescription, #Mycosis, #EnterovirusD68, #DomesticViolence, #WeightStigma, #HealthEquity, #ClimateCrisis, #Measles, #DisastersCost, #ChronicDiseasePrevention, and much more.

The June issue of @lancetgastrohep.bsky.social is out now - www.thelancet.com/journals/lan... Content includes: #MASLD, #alcohol, #roboticsurgery, #oesophagealcancer, #viralhepatitis, #AMR, #cirrhosis + more! #GastroSky #OncSky #MedSky #LiverSky