#RobSelects preprint of the week #ChemRxiv: Dithiophosphoric acids as organocatalysts for radical chemistry. #catalysis https://doi.org/10.26434/chemrxiv.15006758/v1

#RobSelects preprint of the week #ChemRxiv: Mitsunobu reaction via iminophosphoranes formed in situ from aryl azides and trialkyl phosphines. #orgchem https://doi.org/10.26434/chemrxiv.15006188/v2

#RobSelects preprint of the week #ChemRxiv: Nickel-catalyzed enantioselective cross-coupling of alpha-bromo amides with alkylzirconocenes under blue light irradiation #catalysis https://doi.org/10.26434/chemrxiv.15005912/v1

#RobSelects paper of the week #angew_chem: Deaminative alkynylation of aliphatic primary amines with alkynyl bromides. #orgchem https://doi.org/10.1002/anie.1809869

#RobSelects preprint of the week #ChemRxiv: Nickel(0)-olefin pincer-catalyzed hydrogenation of carbonyls under mild conditions. #catalysis https://doi.org/10.26434/chemrxiv.15005286/v1

#RobSelects paper of the week #angew_chem: Chiral phosphine-ligated enantioselective palladium-catalyzed aminoarylation of protected ortho-allyl anilines with aryl bromides. #catalysis https://doi.org/10.1002/anie.8602143

#RobSelects preprint of the week #ChemRxiv: Telemetry enables continuous thermometric and calorimetric monitoring of chemical reactions. #autochem https://doi.org/10.26434/chemrxiv.15005162/v1

#RobSelects paper of the week #Chem: Copper-catalyzed enantioconvergent coupling of alkyl radicals with secondary phosphine oxides. #catalysis https://doi.org/10.1016/j.chempr.2026.103100

#RobSelects preprint of the week #ChemRxiv: Photocatalyzed sulfonylative Pauson-Khand type reaction on 1,6-enynes. #catalysis https://doi.org/10.26434/chemrxiv.15004788/v1

#RobSelects paper of the week #NatureChemistry: Switchable copper-catalyzed N-alpha or N-beta arylation of 3-substituted pyrazoles via ligand choice #catalysis https://doi.org/10.1038/s41557-026-02148-z

Copper-catalysed site-selective arylation of pyrazoles - Nature Chemistry

N-aryl pyrazole is a prevalent motif among pharmaceuticals across various therapeutic areas but can be challenging to synthesize due to the high similarity of the two nitrogen atoms. Now it has been shown that the use of copper catalysis and arynes provides a switchable protocol to access both regioisomers.

nature.com

#RobSelects preprint of the week #ChemRxiv: A density functional approximation incorporating a multilayer perceptron having integrals of local descriptors as features. #theochem https://doi.org/10.26434/chemrxiv.15004450/v2

#RobSelects paper of the week #J_A_C_S: Ortho-carbon-hydrogen-alyklation of bromoarenes catalyzed by an imidazole-olefin-ligated palladium complex. #catalysis https://doi.org/10.1021/jacs.6c02010

#RobSelects preprint of the week #ChemRxiv: Multi-agent framework for planning and evaluating safety in chemistry and materials laboratories. #aichem https://doi.org/10.26434/chemrxiv.15004378/v1

#RobSelects paper of the week #OrgLett: Isothiourea-catalyzed enantioselective higher-order cycloaddition of photochemically generated ketenes with triflate-substituted tropolones. #catalysis https://doi.org/10.1021/acs.orglett.6c01642

#RobSelects preprint of the week #ChemRxiv: Reaction of iron carbenes with diazenes to form metallacyclobutanes that undergo subsequent cycloreversion. #orgmet https://doi.org/10.26434/chemrxiv-2025-10kzk/v2

#RobSelects paper of the week #J_A_C_S: Pincer-ligated cobalt-catalyzed four-component carbocarbonylation to form unsymmetric aliphatic ketones. #catalysis https://doi.org/10.1021/jacs.6c06343

#RobSelects preprint of the week #ChemRxiv: Nickel-catalyzed Suzuki-Miyaura cross coupling of ketones with boronic esters via in-situ ketone derivatization. #catalysis https://doi.org/10.26434/chemrxiv.15003005/v1

#RobSelects paper of the week #J_A_C_S: Coupling between two tetrahedral carbon centers from an amine and a carboxylic acid catalyzed by an iron porphyrin forming quaternary carbons. #catalysis https://doi.org/10.1021/jacs.6c05065

#RobSelects preprint of the week #ChemRxiv: Palladium-copper co-catalyzed carbenylative Buchwald-Hartwig coupling between aryl halides, N-tosylhydrazones, and anilines. #catalysis https://doi.org/10.26434/chemrxiv.15002705/v1

#RobSelects paper of the week #JCTC: Incorporating neural networks into the PBE functional for local density-dependent reparameterization of exchange and correlation terms. #aichem https://doi.org/10.1021/acs.jctc.6c00270

#RobSelects preprint of the week #ChemRxiv: Stereoselective nickel metallaphotoredox-catalyzed carbon-carbon cross-coupling of alcohols with gem-dibromoalkenes. #catalysis https://doi.org/10.26434/chemrxiv.15002635/v1

#RobSelects paper of the week ScienceMagazine: Diastereoselective silver-catalyzed carbon-hydrogen activation and carbon-nitrogen bond formation with chiral sulfonimidamide reactants. #catalysis https://doi.org/10.1126/science.aee3321

#RobSelects preprint of the week #ChemRxiv: Addition of hydroxylamines across cyclooctynes to form nitrones. #orgchem https://doi.org/10.26434/chemrxiv.15002347/v1

#RobSelects paper of the week #NatureCatalysis: Atroposelective nucleophilic aromatic substitution of fluoronaphthalenes with phenols catalyzed by a chiral phosphonium salt. #catalysis https://doi.org/10.1038/s41929-026-01522-x

Atroposelective organocatalytic nucleophilic aromatic substitution for C–O bond construction - Nature Catalysis

Catalytic access to axially chiral diaryl ethers remains limited by the difficulty of enantioselective C–O bond formation. Now peptide-mimic phosphonium salts enable atroposelective nucleophilic aromatic substitution-driven C–O bond construction, affording axially enantioenriched diaryl ethers.

nature.com

#RobSelects preprint of the week #ChemRxiv: Integrating deep generative models into automated transition state discovery workflows. #aichem https://doi.org/10.26434/chemrxiv.15002135/v1

#RobSelects paper of the week #ScienceMagazine: Carbazole-substituted pyridine bis(oxazoline) complexes as a readily accessible family of potent chiral photocatalysts. #catalysis https://doi.org/10.1126/science.aeb5832

#RobSelects preprint of the week #ChemRxiv: Methylbutyl boronate salt as methylation reagent in Suzuki-Miyaura cross couplings. #catalysis https://doi.org/10.26434/chemrxiv.15001572/v1

#RobSelects paper of the week #J_A_C_S: Excited-state nucleophilic aromatic substitution of nitroarenes. #orgchem https://doi.org/10.1021/jacs.5c21841

#RobSelects paper of the week #ScienceMagazine: Approaching a liquid-liquid critical point in supercooled water via infrared ultrafast laser pulses. #physchem https://doi.org/10.1126/science.aec0018

#RobSelects paper of the week J_A_C_S: Discovering approximate non-iterative algorithms for matrix-based electronic structure calculations via symbolic regression. #compchem https://doi.org/10.1021/jacs.5c22323