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@rogerdjp.bsky.social

Neurogeneticist studying the neurobiology of behaviour and physiology in Caenorhabditis elegans. See monash.edu/discovery-institute/pocock-lab

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🏳️‍🌈🪱🧬@rogerdjp.bsky.social · 7mo ago

I'm excited to share our PNAS paper from 1st author Rebecca Cornell. We reveal that preemptive enhancement of stress responses can be triggered to combat metabolic challenges. Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress | PNAS www.pnas.org/doi/10.1073/...

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress | PNAS

The mitochondrial unfolded protein response (UPRmt) is triggered by cells to alleviate proteotoxicity in response to metabolic stress. The ability ...

pnas.org

Coakley Lab@coakleylab.bsky.social · 9mo ago

Latest paper is now out and features on the cover of Science Advances 👉 tinyurl.com/vea5862x Very grateful Igor Bonacossa Pereira, Dat Le & Massimo Hilliard @hilliardlab.bsky.social for their creativity & passion. Read more about it 👉 tinyurl.com/56awjda5 & 👉 tinyurl.com/2vp8p8uk

An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons

An epidermal membrane periodic scaffold protects axons from damage.

tinyurl.com

🏳️‍🌈🪱🧬@rogerdjp.bsky.social · last yr.

Check out our pre-print on how gas sensing neurons enable animals to anticipate mitochondrial stress! www.biorxiv.org/content/10.1...

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress

Animals integrate environmental and internal cues to maintain homeostasis and health. The mitochondrial stress response is an essential cytoprotective mechanism, and priming its activation provides a survival advantage. Here, we show that the Caenorhabditis elegans receptor guanylyl cyclase GCY-9 regulates neuropeptide signalling from carbon dioxide sensing neurons to govern a non-canonical mitochondrial stress response in the intestine. This stress response induces atypical mitochondrial chaperone transcription, confers mitochondrial stress resistance, and increases mitochondrial membrane potential and respiration. GCY-9 loss disrupts pathogen avoidance, leading to indiscriminate feeding. We show that starvation decreases GCY-9 expression and propose that the resultant cytoprotective program is launched to offset risks associated with this behaviour. Thus, environmental sensing by peripheral neurons can pre-emptively enhance systemic mitochondrial function in response to metabolic uncertainty. One-Sentence Summary Protecting mitochondria by integrating environmental signals ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, GNT1137645, GNT2000766

biorxiv.org