Ronan Kapetanovic
@ronankp.bsky.social
Researcher in Immunology host-pathogen interaction, Macrophage vs Salmonella, 🔬🦠 (He/Him) | France, Tours, ISP, INRAE.fr | Former DECRA & MSCA.IF Fellow
Our work is finally out in Science Immunology ! This was an Amazing collaborative work from all co-authors, in particular the two co-first authors James Curson and Syeda Farhana Afroz . Never give up ! :) www.science.org/doi/10.1126/...
Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response
Mitochondrial fission promotes antibacterial defense via the mitochondrial unfolded protein response and inducible lipid droplets.
science.org
Back on BlueSky after a long break ! Really happy to see the work of Jess finally out ! Amazing collaboration with UQ - in particular M.Schembri & M.Sweet! www.pnas.org/doi/10.1073/...
Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense | PNAS
Mechanisms by which macrophages deploy antibacterial zinc toxicity are poorly understood. To gain insight into this antimicrobial pathway, we devel...
pnas.org
Went to basel last week for a Farewell Seminar for Patrick Matthias at the FMI. Really enjoyed meeting old alumni of Patrick’s lab. Enjoy your new adventure Patrick!!
Happy to share our last paper. We show that the inoculation of 4 commensal bacteria to chicks has both short- and long-term effects on immune response and microbiota composition and promoted the low-shedder phenotype thanks to a more fermentative microbiota. www.tandfonline.com/doi/full/10....
The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonization
Super- and low-shedding phenomena have been observed in genetically homogeneous hosts infected by a single bacterial strain. To decipher the mechanisms underlying these phenotypes, we conducted an ...
tandfonline.com
We are looking for a PhD candidate starting on the 01-10-2025. The project aims to understand how the host cells use copper and oxidative species to fight Salmonella infection and how this pathogen evades this antimicrobial response. SHORT DEADLINE ! 20-04-2025 jobs.inrae.fr/en/ot-25517
First snow this year in Touraine, France at my workplace (it’s been a few years without I heard)! Cold 🥶 but so happy to see some snow ⛄️
Nice work from @laurenpalmer.bsky.social ! Showing once more the important link between zinc, inflammation and antimicrobial response, Here, Acinetobacter baumannii.
Lauren Palmer@laurenpalmer.bsky.social · 2y agoSO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜
Perfect project for a post-doc! You will have access to a great set of data and we have already exciting hypotheses! Don’t hesitate to contact us.
Ronan Kapetanovic@ronankp.bsky.social · 2y agoLooking for PostDoc - Metabolism/Salmonella. We are looking for candidates with excellent knowledge in bioinformatics and bacterial physiology / microbial ecology. We will help the candidate to build a successful application for European grants such as EMBO and Marie Skłodowska-Curie Actions.
Looking for PostDoc - Metabolism/Salmonella. We are looking for candidates with excellent knowledge in bioinformatics and bacterial physiology / microbial ecology. We will help the candidate to build a successful application for European grants such as EMBO and Marie Skłodowska-Curie Actions.
With all the new people, perhaps I should post an introduction. I am an immunologist identifying new antimicrobial responses in macrophages. My current research focuses on the use of metal ions (Zn & Cu) vs Salmonella infection. Always love to meet new faces and set up new collaborations. 🔬🦠
It’s out ! Our review on antibacterial responses in macrophages in @NatRevImmunol . We tried to cover as many pathways as we can, macrophages always astonish me by their immense arsenal. Very happy to have collaborated on that paper ! Version online FREE: rdcu.be/dUlUZ
Inducible antibacterial responses in macrophages
Nature Reviews Immunology - Macrophages are innate immune sentinels providing frontline defence against infection. This Review describes the inducible mechanisms used by macrophages to kill...
rdcu.be
Good News ! We are looking for a PhD student to work on understanding the role of zinc in the host response to Salmonella. How macrophage use the Zn? How Salmonella resist Zn and can escape this antimicrobial weapon? Deadline 31.05.24 to start 01-10-2024. jobs.inrae.fr/en/ot-21883
Super stoke with the publication of this work ! Amazing job from @KaustavDasGupt8 and James to carry out the work ! How the heavy metal zinc is linked to antimicrobial response in CF patients. doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
Music Brings People Together 🎶 A nice project from one of my friends to establish his awesome Music School close to Tours, France. Every little donation is worth a lot for them ! www.kisskissbankbank.com/fr/projects/...
Last few days before deadline!
Ronan Kapetanovic@ronankp.bsky.social · 3y agoGood news ! I’m looking for a post-doc (1 year ½ contract) to join our MiMoSa team at the @INRAE_VDL . Host-pathogen interaction project on understanding the dynamic of Zn and Cu during Salmonella infection. Deadline: Feb 11th, 2024. jobs.inrae.fr/en/ot-19561
Biology is never simple ! I’m happy to share our new publication on the role of HDAC6 on inflammasome. We used several methods (KO mouse, inhibitors, DARPIN…) to show that HDAC6 is NOT always driving the inflammasome and is context-dependent. DOI:https://doi.org/10.1016/j.jbc.2024.105638
Good news ! I’m looking for a post-doc (1 year ½ contract) to join our MiMoSa team at the @INRAE_VDL . Host-pathogen interaction project on understanding the dynamic of Zn and Cu during Salmonella infection. Deadline: Feb 11th, 2024. jobs.inrae.fr/en/ot-19561
I finally made it onto BlueSky ! I'm rebuilding my network slowly. I will try to update regularly my profile with (mostly) science while setting up my research at the INRAE ! Macrophages, Salmonella, metal ions (zinc) & mitochondria
