Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear. Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA. www.cell.com/molecular-ce...
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
Squair et al. show that ZNFX1 restricts ssRNA virus replication by integrating SF1 helicase activity with dual E3 ligase mechanisms. ATP-dependent RNA binding activates E3 function, driving self-propa...
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