Don't miss research in our latest issue from Hongyan Li, Hongzhe Sun & co. at the University of Hong Kong showcasing the use of a bismuth drug as an antibiotic adjuvant to inhibit biofilm formation #medchem Check it out on our website🔽 doi.org/10.1039/d6md...

🔓Check out this review by Celine Cano et al. from @newcastleuni.bsky.social in our latest issue providing insights into the discovery and optimisation of DNA-PK inhibitors #medchem Read the full article below👇 doi.org/10.1039/d6md...

Take a look in our latest issue at research from Toshio Morikawa, Genzoh Tanabe & co. investigating the structure activity relationship of the indole 2-S-,3-O-bis-glucoside calanthoside #medchem 📍Kindai University doi.org/10.1039/d6md...

Be sure to read this review from Zihao Liu & Zhiguang Yang at Jilin University in our latest issue discussing the progress of histone deacetylase-based dual inhibitors in non-small cell lung cancer therapy #medchem Find their full article on our website👇 doi.org/10.1039/d6md...

🔓Don't miss #OpenAccess research in our latest issue by Ioannis K. Kostakis & co. from the University of Athens reporting novel hydroxytyrosol esters as potential anti-amyloid and neuroprotective agents for Alzheimer's disease #medchem Check it out in full here🔽 doi.org/10.1039/d6md...

📢Our latest issue is now online! Check out the research behind the cover by Oleksandr O. Grygorenko & co. from Enamine & University of Kyiv describing the structure–activity relationships in a series of dihydrouracil–JQ1 conjugates #medchem doi.org/10.1039/d6md...

Be sure to read this review by Mahdi Gallala et al. from Monastir University in our latest issue discussing the recent advances in the development of acridine-based hybrids with antiproliferative activity #medchem Find their full article below👇 doi.org/10.1039/d6md...

🔓Don't miss this #OpenAccess research in our latest issue from @danielecastagnolo.bsky.social & co. @ucl.ac.uk & @kingscollegelondon.bsky.social describing light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids #medchem Check it out here🔽 doi.org/10.1039/d6md...

Take a look at this review from Yan Li, Honghua Zhang & co. in our latest issue looking at small-molecule therapeutics for diabetic retinopathy #medchem 📍National University of Singapore & Lanzhou University doi.org/10.1039/d6md...

Be sure to read this paper in our latest issue by Srikanta Patra, Debasis Manna et al. at IIT Guwahati & IIT Bhubaneswar addressing multidrug-resistant bacterial infections with iridium-based theragnostic agents #medchem Find it in full below👇 doi.org/10.1039/d6md...

🔓Don't miss in our latest issue #OpenAccess research by Gonzalo Rodriguez-Berriguete, Christopher J. Schofield, Geoff S. Higgins & co. @ox.ac.uk reporting structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors #medchem Check it out here🔽 doi.org/10.1039/d5md...

Check out this review by Fengxia Sun, Yunfei Da et al. from Tianjin University in our latest issue discussing the targets, pharmacological properties and SAR studies of sulfone and sulfoxide-containing pharmaceuticals #medchem Read it in full on our website🔽 doi.org/10.1039/d5md...

Take a look in our latest issue at research by Patrícia Dias Fernandes & co. reporting new terpenyl–cinnamoyl–hydrazone analogues of cannabidiol with potent antinociceptive effect #medchem 📍 @ufrjoficial.bsky.social & @unifalmg.bsky.social doi.org/10.1039/d6md...

🔓Be sure to read this #OpenAccess research from Shinya Oishi et al. at Kyoto Pharmaceutical University in our latest issue identifying minimal fusion inhibitors targeting measles virus F protein #medchem Find their full report on our website👇

Identification and structure–activity relationship analysis of minimal fusion inhibitors targeting measles virus F protein

Although measles has been effectively controlled by vaccination, sporadic outbreaks still occur worldwide, highlighting the need for antiviral agents as complementary measures to achieve sustained…

doi.org

🔓Don't miss this #OpenAccess review in our latest issue by Martin R. Gill from Swansea University discussing the mechanisms and therapeutic implications of the relationship between Ruthenium(ii) polypyridyl complexes and the DNA damage response #medchem Check it out in full🔽

Ruthenium(II) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Ruthenium(ii) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is…

doi.org

🎉We were delighted to have @fleurmferguson.bsky.social's 2026 RSC Medicinal Chemistry Emerging Investigator Lectureship presented at the Induced Proximity Modalities & Therapeutics GRC this month! A huge congratulations to Fleur again on being selected for this year's Lectureship #chemsky #medchem

📢Our latest issue is now online! Check out the article behind the cover by Nikolai Petrovsky, Janardhan Banothu & co. at NIT Calicut & Panjab University describing bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as TLR2 agonists #medchem pubs.rsc.org/en/content/a...

Take a look in our latest issue at this review from Philip E. Thompson & co. highlighting the diverse ring architectures of cyclic peptidomimetics targeting melanocortin receptors #medchem 📍 @monashuniversity.bsky.social

Diverse ring architectures of cyclic peptidomimetics targeting melanocortin receptors

The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) that are activated by peptide hormones α, β and γ-MSH and ACTH. These receptors are involved in diverse…

pubs.rsc.org

Be sure to read a paper by Lei Wang, Engin U. Akkaya et al. from the Dalian University of Technology in our latest issue reporting hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming #medchem Find the full article here🔽

Hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming

Dichloroacetate (DCA) is a known inhibitor of pyruvate dehydrogenase kinase, which is part of the key enzyme complex in metabolic reprogramming of cancer cells. In this work, we structurally modified…

pubs.rsc.org

We're excited to announce the winners of our 2026 RSC Prizes! More than 60 talented individuals and teams from around the globe are being celebrated today for their work on everything from solar energy and drug discovery to materials chemistry and AI. 👉 https://rsc.li/3SgSapw #RSCPrizes #ChemSky

Don't miss this review in our latest issue from Rahul Kumar & Mohd Yeshab Ansari at CSIR-IHBT & CSIR-CDRI discussing the synthesis and therapeutic potential of antimicrobials in oncology #medchem Check it out in full on our website👇

Beyond infection control: exploring the therapeutic potential of antimicrobials in oncology and their synthetic perspectives

The repurposing of FDA-approved antimicrobial agents for oncology presents a promising therapeutic strategy to accelerate drug development and enhance clinical outcomes in cancer therapy. This…

pubs.rsc.org

🔓Check out #OpenAccess research by Paul M. Dunman, Christian Melander & co. @notredame.bsky.social & @urochester.bsky.social in our latest issue exploring a benzothiophene scaffold for use as adjuvants with β-lactam antibiotics against MRSA #medchem Find in full below🔽

Exploration of a benzothiophene scaffold for use as adjuvants with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Rising antibiotic resistance coupled with diminishing investment in antibiotic development has led to limited treatment options for multi drug-resistant bacterial infections. Penicillin binding…

pubs.rsc.org

Take a look at a paper in our latest issue from Mansour S. Alturki, Marwa F. Ahmed, Atiah H. Almalki et al. on the design, synthesis & anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids #medchem 📍Imam Abdulrahman Bin Faisal University, Taif University

Design, synthesis, and anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids: in vitro and computational insights into EGFR inhibition

A novel series of pyrrole–pyrazoline/chalcone hybrids were designed, synthesized and evaluated for antiproliferative activity to target epidermal growth factor receptor (EGFR) inhibition. All the…

pubs.rsc.org

Be sure to read research in our latest issue by Jeffrey W. Strovel, Steven Fletcher & co. @univofmaryland.bsky.social describing lead optimization of a quinolin-2(1H)-one-based inhibitor of the BRD4 member of BET protein family #medchem Find their full report here👇

Lead optimization of 5jc21 (CG13250), a quinolin-2(1H)-one-based inhibitor of the BRD4 member of the bromodomain and extraterminal (BET) family of proteins

The inhibition of the BET BRD4 protein has rapidly emerged as an indirect means of inhibiting the intrinsically disordered c-Myc proto-oncoprotein, a “holy grail” in oncology. Herein, we conducted…

pubs.rsc.org

Don't miss this review from Fule Wu, Muneeb Ur Rehman, Sihui Long et al. at the Wuhan Institute of Technology in our latest issue providing a holistic view of the pharmacological landscape of carbolines #medchem Check it out on our website🔽

Pharmacological landscape of carbolines: a holistic view

Natural resources have served as a cornerstone for the discovery of innovative pharmaceutical compounds for millennia. Among the diverse natural compounds demonstrating significant pharmacological…

pubs.rsc.org

🔓Check out this #OpenAccess paper in our latest issue by Zafer Asım Kaplancıklı & co. from Anadolu University reporting quinoline/thiazole compounds as selective acetylcholinesterase inhibitors #medchem Read it in full below👇

Quinoline/thiazole compounds as selective acetylcholinesterase inhibitors: synthesis and biological assessment

Acetylcholine (ACh), acetylcholinesterase enzyme (AChE), and AChE inhibition are of great importance in the treatment of neurodegenerative diseases. When it comes to AChE inhibition, FDA-approved…

pubs.rsc.org

Take a look at research by Adam McCluskey et al. in our latest issue investigating the clathrin inhibitory effects of substituted naphthoquinones #medchem 📍University of Newcastle, University of Queensland, @sydney.edu.au & @fmp-berlin.de

From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects

Bolinaquinone (BLQ, 1), a hydroxyquinone sesquiterpene, has been reported to inhibit clathrin mediated endocytosis. As there is no reported clathrin IC50 or commercial source of BLQ, we examined the…

pubs.rsc.org

🔓Be sure to read this #OpenAccess review in our latest issue by Hakon Hakonarson & co. @childrensphila.bsky.social looking at the role of the thiol-based agent N-acetylcysteine in human health and disease #medchem Find it in full here👇

Redefining the role of the thiol-based agent N-acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative

N-Acetylcysteine (NAC) is the established antidote for acetaminophen toxicity and an approved mucolytic agent. Beyond these traditional uses, increasing evidence highlights its broader role as a…

pubs.rsc.org

🔓Don't miss this #OpenAccess review from Kagan Kerman & co. @chemuoft.bsky.social in our latest issue exploring the latest developments in modulators, antibody therapy and gene therapy targeting BACE1 #medchem Check it out in full on our website🔽 pubs.rsc.org/en/content/a...

Recent advances towards BACE1 drug discovery and therapeutics design

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. A key feature of AD is the accumulation of amyloid beta (Aβ) peptides in the fo...

pubs.rsc.org

📢 We are excited to announce this year’s Chemical Science symposium on the topic of digital chemistry in the age of AI and machine learning! Find out more at rsc.li/chemscisymp2026 The symposium will be held in London, UK on the 29th and 30th of October 2026 in person only. #ChemSciSymposium