RSC Pharmaceutics

@rscpharmaceutics.rsc.org

Leading the way in drug delivery, formulation, and pharmaceutical technology. Published by @rsc.org 🌐 Website: rsc.li/rscpharmaceutics

RSC Pharmaceutics has reached an important milestone – its first Journal Impact Factor of 5.5. The work focusses on emerging technologies, including drug delivery, precision medicine and enhanced drug targeting, with potential to drive real change in health. Discover our metrics ➡ buff.ly/Os2BVlM

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RSC Pharmaceutics Advisory Board member Emily Day and team demonstrate that fluorescent dye micelles can be present in dye-labelled nanoparticle solutions, giving false positive results for nanoparticle tracking. Luckily, they also explore potential separation techniques! doi.org/10.1039/D5PM...

Standard purification methods are not sufficient to remove micellular lipophilic dye from polymer nanoparticle solution

Tracking nanoparticles’ location is imperative for understanding cellular interactions, pharmacokinetics, and biodistribution. DiD is a lipophilic dye commonly used to label nanoparticles for traffick...

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Olivia Merkel and team report a DoE-driven screening on an automated microfluidic small-scale device which enabled identification of stable RNA/PBAE nanoparticles. Transfer of optimized process parameters to a large-scale device confirmed robust and scalable manufacturing 🧪

QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidics

Poly(β-amino ester) (PBAE)-based nanoparticles have emerged as promising carriers for RNA delivery, yet clear design rules linking formulation parameters to performance are still lacking. In this…

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