Here's a peek at the associated Commentary by Carlos Carmona-Fontaine: doi.org/10.1172/JCI1...

We're delighted to announce a brand new meeting series, joining the Fusion community in May 2027. *Translational Control - From Cells to Organisms Conference* 📅Date: 22 - 25 May 2027 🌏Location: Durrës, Albania Sign up for updates to find out more information on the conference: bit.ly/4eGxaQG

Transformative work from the @mbarnalab.bsky.social Ribo-Tweezer enables direct interrogation of ribosomal protein (RP) function in mature ribosomes, revealing that distinct RPs control unique translatomes and that RACK1 removal rewires translation and stem cell identity. Congrats to all!

Maria Barna@mbarnalab.bsky.social · 3mo ago

’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

A fascinating connection between translation decoding specificity through metabolites that help cells control a vital redox state. Congrats Josh @mendell-lab.bsky.social and Fred! @fred-rehfeld.bsky.social

Josh Mendell@mendell-lab.bsky.social · 10mo ago

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

This will be an exciting meeting on many aspects of RNA biology, the impact on tumorigenesis and theraupric implications. Including: Splicing, Noncoding RNA, RNA modifications, Translation, New technologies, RNA and immunology, Protein-RNA assembly, & cancer therapeutics in targeting RNA. Join us!

Eric Van Nostrand Lab @ BCM@evannostrandlab.bsky.social · 12mo ago

If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA! events.faseb.org/event/RNA-Pr...

Small-molecule RNA therapeutics to target prostate cancer

Small-molecule RNA therapeutics to target prostate cancer

Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the select translation of key oncogenes, androgen receptor (AR), and HIF1α through remodeling their 5′ UTR RNA structure. Zotatifin enhances anti-androgen and radiotherapy sensitivity, highlighting a promising anti-cancer treatment.

dlvr.it

Excited to share our first study using nanopore direct RNA seq to comprehensively characterize RNA features. We believe that our deep and high coverage datasets should be a nice resource for the field! www.cell.com/cell-genomic...

Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features

Understanding the interactions between various mRNA features—such as RNA modifications, poly(A) tail length, and splicing—has been highly sought after but remains largely elusive. Here, Kim and Savill...

cell.com

🍰Interested in reading more about the study? Here's the N&Vs article written by Joanna R. Kovalski & Davide Ruggero. 👉https://rdcu.be/ejwqJ bit.ly/4jnydWI

Breaking up translation condensates in cancer - Nature Cell Biology

Translational control is emerging as a key regulator of cancer. The RNA-binding protein PABPC1 is shown to drive chronic myeloid leukaemia (CML) by enhancing the translation of pro-oncogenic mRNAs thr...

bit.ly

Online Now: Ribosomal rebellion: When protein factories drive cancer progression

Ribosomal rebellion: When protein factories drive cancer progression

In Cancer Cell, two studies unveil mechanisms by which co-option of the protein synthesis machinery promotes cancer progression and potential therapeutic interventions. Kuzuoglu-Ozturk et al. show that eIF4A-mediated enhancement of oncogenic transcript translation initiation drives cancer progression, while Weller et al. demonstrate how aberrant transfer RNA (tRNA) modification disrupts translational fidelity to produce neoantigens.

dlvr.it

Fascinating work on noncoding snoRNA sequences on ribosome biogenesis and its implication in cancer cell fitness! Congrats Josh @mendell-lab.bsky.social and team!

Josh Mendell@mendell-lab.bsky.social · last yr.

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇 www.cell.com/molecular-ce...

Thanks Levi Gadye and Laura Kurtzman for the thoughtful and creative press release! @UCSF @UCSFCancer x.com/UCSFCancer/sta…

And we couldn't make it without @PCFnews @pcarroll_ and Benioff Initiative for Prostate Cancer Research support! cell.com/cancer-cell/fu…

Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to ⁦@DuyguKuzuoglu⁩ an amazing postdoc and all the authors and collaborators! cell.com/cancer-cell/fu…

Great tools and tips for the field to study IRES-dependent translation. Beautiful dissection of true HOX IRES translation in developing embryos. Congrats to all @mbarnalab @KatLeppek! x.com/mbarnalab/stat…

A tour de force in deciphering in action the intriguing dynamic composition of ribosomes in vivo. Beautiful work! Congrats to all @mbarnalab! x.com/mbarnalab/stat…

Thanks Levi Gadye, for the wonderful and insightful highlight of our last publication! @UCSF ucsf.edu/news/2025/02/4…

Congrats @mbarnalab @travisclantz and Christine on this award and making progress on targeting ribosomes to increase protein synthesis! x.com/mbarnalab/stat…

Congrats on this beautiful paper on another great link between lipid metabolism and translation control! @DeSiqueiraMK, @ClaudioVillanu, and team! x.com/DeSiqueiraMK/s…

Amazing work on uncovering a new role for tRNAs in linking mRNA stability with codon-specific translation! Congrats @Mendell_lab and team!! x.com/Mendell_lab/st…

Amazing paper on specialized ribosomes and their roles in cancer immune response! Congrats @liamfaller and all team! t.co/yR2JfIZOTp

Thanks @RNACanadaC2R2 for organizing an amazing RNA meeting! x.com/RNACanadaC2R2/…

Fantastic collaboration with the @mbarnalab @TheVictoriaHung @AndrewL85556734 Theo and team on ribosome composition in cancer, development and macrophages. @UCSFCancer @ACS_Research @StanfordMed x.com/MolecularCell/…

Thanks so much Levi Gadye @UCSFCancer @UCSFMedicine for this wonderful summary of our recent research! x.com/UCSF/status/18…

Congrats Daphna @D_Rothschild_ Theo, and team @mbarnalab Beautiful and important work. x.com/D_Rothschild_/…

Fascinating work on noncoding snoRNA sequences on ribosome biogenesis! Congrats Josh @Mendell_lab and team! x.com/Mendell_lab/st…

Ribosomal protein (rpl40) methylation regulates mRNA translation critical for gastric cancer opening new therapies. Congrats to all! nature.com/articles/s4158…

Fascinating work unveiling a specific function of CNOT3 as a key regulator of translation control in cancer. Congrats Ly @Vuphuongly and team! x.com/Vuphuongly/sta…

Fascinating work on the interaction between 5’UTR alternative splicing and translation control in cancer and therapy. Congrats @andrei_thomas_t and all collaborators! x.com/andrei_thomas_…

Exciting work from @Sorrell_Lab! Congrats to all! x.com/Sorrell_Lab/st…

So proud of Joanna @ScientistJoanna! She is an amazing and inspirational scientist. Thanks to the ACS support! @AmericanCancer @ACS_Research @UCSFUrology @UCSFCancer x.com/billdahutmd/st…