Tessera

AMR-kleb/staph

@s-rowe-conlon.bsky.social

Nadia Nikulin, PhD @nadianikulin.bsky.social · 6mo ago

First paper of my PhD @doerrlab.bsky.social is up! We characterized meropenem tolerance in Enterobacterales species, and then further dissected tolerance mechanisms in Klebsiella pneumoniae. journals.plos.org/plospathogen...

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae

Author summary Bacteria can survive exposure to antibiotics by constantly repairing cellular damage induced by the drug. This “antibiotic tolerance” enables diverse bacteria to survive long enough to ...

journals.plos.org

Caity Holmes @caityholmes.bsky.social · 5mo ago

My lab's first paper is out! We tested the ability of Klebsiella bacteremia fitness factors to enhance resistance to oxidative, nitrosative, and intracellular stress. Bacteremia fitness is significantly linked to nitrosative and macrophage-mediated stress resistance. journals.asm.org/doi/10.1128/...

AMR-kleb/staph @s-rowe-conlon.bsky.social · 8mo ago

Thrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.social

Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations | PNAS

Liver abscesses caused by hypervirulent Klebsiella pneumoniae (hvKp) can lead to severe metastatic complications, with mortality rates ranging from...

pnas.org

AMR-kleb/staph @s-rowe-conlon.bsky.social · 2y ago

Great work from Zajeba Tabashsum, a very talented postdoc in my lab. Her paper describes how a host produced unsaturated fatty acid (palmitoleic acid) overcomes vancomycin resistance in VRSA strains. #AMR #Staphaureus journals.asm.org/doi/10.1128/...

Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes | Microbiology Spectrum

The development of antibiotics has transformed medicine, reducing the incidence and severity of bacterial infections and allowing for advancements in healthcare, including invasive surgeries and organ...

journals.asm.org