Tessera

@sambooker.bsky.social

We just published a thing! www.frontiersin.org/journals/pha... Here we show that somatostatin interneurons display exaggerated LTP in a mouse model of Fragile X Syndrome, and which is sensitive to GABAB receptor activation; but which are not manifested at the circuit level - more work to do!

Frontiers | Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome

IntroductionFragile X Syndrome is a common, inherited single gene cause of intellectual disability, associated with autism, epilepsy, anxiety, and sensory di...

frontiersin.org

Edinburgh Neuroscience @edinunineuro.bsky.social · 10mo ago

New @who.int Global Status Report on Neurology calls for urgent action to address the growing burden of neurological disorders & to promote brain health for ALL. @arinatam.bsky.social co-authored Ch4: Effective, timely & responsive diagnosis, treatment & care. Full report: edin.ac/43r3P7U

who.int

WHO@who.int · 10mo ago

1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism. Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH

Over 3 billon people live with neurological disorders

@sambooker.bsky.social · 10mo ago

www.biorxiv.org/content/10.1... super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.

FMRP regulates adult human cortical excitability via cyclic-AMP signalling

Fragile X Syndrome (FXS) is a common inherited neurodevelopmental condition, resulting from loss of Fragile X Messenger Ribonuclear Protein (FMRP). Rodent models of FXS display cellular hyperexcitabil...

biorxiv.org

@sambooker.bsky.social · 11mo ago

Hello world! We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 11mo ago

Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits https://www.biorxiv.org/content/10.1101/2025.09.01.672986v1

Simons Foundation @simonsfoundation.org · 12mo ago

Meet the Simons Initiative for the Developing Brain: a center devoted to deconstructing the secrets of neurodevelopmental disorders and the developing brain. Read more: annualreports.simonsfoundation.org/2024/scottis... #science #neuroscience

Scottish Neuroscience Initiative Takes Basic Science From Lab to Clinic

The Simons Initiative for the Developing Brain aims to discover biological mechanisms underlying autism and related neurodevelopmental disorders and to use that information to deliver therapeutic…

annualreports.simonsfoundation.org

@sambooker.bsky.social · last yr.

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications

GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...

nature.com

Dr Soraya M @sorayam.bsky.social · last yr.

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

rdcu.be

@sambooker.bsky.social · last yr.

Friday saw two momentous occasions. The first major study accepted from our lab 🥳 and my 5 year old reciting to me the principles of synaptic strengthening in learning and memory. Immensely proud of both...

@sambooker.bsky.social · 2y ago

We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

nature.com