Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

nature.com

mSphere of Influence: Revisiting the central dogma, again! | mSphere

The idea that information flows from DNA to RNA to protein with an exception involving reverse transcription has stood the test of time. Protein-coding genes have been known to be encoded in a nucleic...

journals.asm.org

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Stress induces threat memory generalization in mice by expanding the engram ensemble in the lateral amygdala via retrograde endocannabinoid signaling on parvalbumin-positive interneurons.

cell.com

De novo gene synthesis by an antiviral reverse transcriptase

Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown....

science.org

Cell-Type-Specific Effect of Innate Immune Signaling on Stress Granules

Stress granules (SGs) are cytoplasmic membraneless compartments that can form in stressed cells. There is an intricate relationship between SGs and innate immune signaling pathways. A previous study r...

mdpi.com

When my lab members started to leave, I felt like a failure as a mentor

“As painful as it has been, this experience taught me several valuable lessons,

science.org

TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experim...

Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the bra...

jneuroinflammation.biomedcentral.com