Congratulations to Charles L. Sawyers @sawyerslabmskcc.bsky.social, Memorial Sloan Kettering Cancer Center, on receiving the Harrington Prize—award lecture happening now!
The Charles Sawyers Lab
@sawyerslabmskcc.bsky.social
Research in the Sawyers Lab focuses on prostate cancer and new therapeutic strategies to block cancer progression. https://www.mskcc.org/research-areas/labs/charles-sawyers
Congratulations, Emmet!! @ehuanghobbs.bsky.social www.nyas.org/press-releas... @mskcancercenter.bsky.social #TheNewYorkAcademyofSciences #SawyersLab
In 2026, the Human Oncology and Pathogenesis Program (HOPP) celebrates 20 years of discovery, leadership, and impact in translational oncology. We are pleased to share symposium highlight videos from the HOPP 20 Year Anniversary page: www.mskcc.org/research-pro... @mskcancercenter.bsky.social
Human Oncology and Pathogenesis Program: 20 Year Anniversary | Memorial Sloan Kettering Cancer Center
In 2026, the Human Oncology and Pathogenesis Program (HOPP) celebrates 20 years of discovery, leadership, and impact in translational oncology. HOPP supports innovation and collaboration between talen...
mskcc.org
OUT NOW: FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity: Cell Reports www.cell.com/cell-reports... @mskcancercenter.bsky.social @cellpress.bsky.social @erikladewig.bsky.social #SawyersLabMSKCC
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Ladewig et al. show that distinct Foxa1 mutations reprogram chromatin, altering epithelial lineage specification. Indels promote basal-like states, whereas C-terminal truncations, Wing2 missense mutat...
cell.com
Meet #MSKPostdoc Agnieszka Chryplewicz (@aga-chryplewicz.bsky.social) from the @sawyerslabmskcc.bsky.social! She studies how tumor-derived factors in prostate cancer shape immune responses to promote tumor growth and limit treatment success. #NPAW2025 🇵🇱
While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉 🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab 🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social 🥉 Manendra Lankadasari – Jones lab Congrats to our amazing #MSKPostdocs! 👏📷
OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
Nature Genetics - Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an...
rdcu.be
Just out: BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function | PNAS www.pnas.org/doi/10.1073/... @mskcancercenter.bsky.social @kyriepappas.bsky.social #SawyersLabMSKCC
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
OUT NOW: Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers | Science Advances www.science.org/doi/10.1126/... #SawyersLab #MSKCC @mskcancercenter.bsky.social
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
Restoration of downstream mTOR signaling causes resistance to combined Akt and androgen receptor blockade in prostate cancer.
science.org