Aleksejs Sazonovs
@sazonovs.bsky.social
IBD genomics. Views expressed in different tissues
The coffee shop needs to either fix the toilets or stop playing One More Cup of Coffee
Well done Michelle
Congratulations to Michelle Sollok on receiving a prestigious DARA PhD Fellowship! 🎉 She will study how DNA methylation links genetics, environment and IBD risk—helping identify modifiable factors for better prediction and prevention. A well-deserved achievement! @dg.dk @aau.dk @sazonovs.bsky.social
There’s basically no moral case for having any import duties for solar
Probably the best example of a rapid bottom-up energy transition: Pakistan imported more Chinese solar last year than any country on earth. No big subsidy, no rooftop scheme, no feed-in tariff. Solar is now around a quarter of electricity. More in my piece👇 www.thenewworld.co.uk/jan-rosenow-...
And on the plinth, the value proposition was still visible: “My name is Ozymandias, category leader among leaders. Benchmark your achievements against mine, high performers, and reconsider your strategy.”
A wonderful #HumanProteomeAndHealth symposium at Oxford in the past two days. It was a great pleasure to see our trainees showcase their hard work and research. #proudPI👏🎉
I think the fundamental limitation of the art form is that, financial cancellations aside, basically *every series*
What about this: Name your fav TV show that was cancelled too *late*
Never quite appreciated the final stat (1 in 5 are top 1% PRS for some disease)
Caroline Wright (Exeter) sharing fundamental knowledge What does the "average" human genome look like?" >900k 🧬 #UKB / #AllofUs / Genome: 1️⃣ ~4.4–5.5 million variants 2️⃣ 2–3 ClinVar P/LP (mostly AR) 3️⃣ ~62–70 de novo variants 4️⃣ ~1 in 5 people in top 1% of PRS for ≥1 disease
Australia should consider bringing back the safer fauna to its lands
Scientists share discoveries about Australia's polar past and the dinosaurs that roamed
Has anyone considered the causal role of the unfortunate name of these?
New preprint from the last portion of my PhD! Despite low masked load, we found evidence for strong inbreeding depression in Devils Hole pupfish. The reason? A recessive lethal haplotype that causes a heart defect among developing embryos. www.biorxiv.org/content/10.6...
The hatred for Gladwell feels a bit snobbish. Give him a chance – spend some time getting to know him. Maybe 10,000 hours?
This is like Oasis ticket sales, except for people who like Blur
Europe should really have the same debate we’ve had for three decades about ditching Microsoft – especially now that the number of European tech products is somehow going into negative digits
🇪🇺 Meet EuroOffice, Europe’s bold alternative to Microsoft 365, promising sovereignty and control It is based on OnlyOffice and offers a near-like-for-like experience as Microsoft for free. Something for everyone to check out, not only Europeans.
Can’t believe this isn’t a bigger story. Most biomedical research runs on Thermo and trusts the company’s own validation claims. They need to go thermonuclear and explain how this happened
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!
In case of emergency blow up the rebel scum on Alderaan
I think “critique” of any big society-changing phenomenon is incredibly important, but we’re in a situation where the cutting edge stuff regurgitates the stochastic parrot and plagiarism machine memes while Tim Gowers is writing that it’s about to change maths as a profession. Dem parrots smart
OpenAI's claim that this is a central conjecture in discrete geometry is not an exaggeration. This will I think be looked back on as the first time that AI solved a major mathematics problem (defined as a problem that all experts in some subfield had thought about). openai.com/index/model-...
Today is World IBD Day. To everyone living with Crohn’s and colitis, and to those by their side: we see the strength it takes, every day
You’re absolutely right to call that out — most people wouldn’t even catch it, but you
People prefer to use “sycophantic” AI systems that reinforce their pre-existing beliefs. In a new paper (n=7,227), we found that people enjoyed interacting with sycophantic AI chatbots more than interacting with neutral chatbots or “disagreeable” chatbots that challenged their beliefs.
If British political drama has taught us anything it’s that Starmer will eventually be deposed by a classmate. Fatboy Slim for Prime Minister
I do not want to single out the particular study but sci journalists need a refresher course on causality
Baiting online academics to write about collider bias all weekend by posting one reasonably bad paper