SBGrid Consortium
@sbgrid.bsky.social
Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software, hosting educational webinars, supporting reproducibility, validation, reprocessing of data, & access to scientific resources sbgrid.org / biogrids.org
New Title Alert: Leopard-EM (Location & oriEntatiOn of PARticles found using two-Dimensional tEmplate Matching) is a python package for running two-dimensional template matching (2DTM) on cryo-EM images. More here: buff.ly/FZ5bVfZ #SBGrid #Software #StructuralBiology
Leopard-EM Homepage - Leopard-EM: Two-Dimensional Template Matching in Python
Overview of the Leopard-EM package for 2DTM in Python
lucaslab-berkeley.github.io
We finished our 2025-2026 Software Webinar season in July with a presentation from @mgflast.bsky.social on Ais, Pom, and easymode. In case you missed it, you can find the recorded version on the SBGridTV YouTube channel: buff.ly/kbQNcdx #Webinars #SBGrid #StructuralBiology
Ais, Pom, and easymode
SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont…
youtube.com
New Title Alert: warpylib- is a Python library replicating core functionality from [WarpLib](buff.ly/t1bv8gU), a C# framework for cryo-electron tomography (cryo-ET) data processing. Built on PyTorch for GPU acceleration and automatic differentiation. More here: buff.ly/j81TW5L #SBGrid #Software
GitHub - warpem/warp
Contribute to warpem/warp development by creating an account on GitHub.
buff.ly
New Member Alert: José Maria Valpuesta from @cnb-csic.bsky.social joined SBGrid in June. Welcome!!
SBGrid's eLife paper received a citation in June from@cryoet.bsky.social from The Johns Hopkins University School of Medicine in @pnas.org: Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15. Read more here: buff.ly/nRGFvb0 #SBGrid #StayConnected
Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 | PNAS
Tip links connect the stereocilia of mechanosensory hair cells in the inner ear and transmit force onto mechanotransduction (MET) channels. Tip lin...
buff.ly
New Member Alert: Jose-Jesus Fernandez from Health Research Institute of Asturias (ISPA) joined SBGrid in June. Welcome!!
New Member Alert: @carmensmp.bsky.social from @cnb-csic.bsky.social joined SBGrid in June. Welcome!!
SBGrid's eLife paper received a citation in June from @yunsunnam.bsky.social from University of Texas Southwestern Medical Center in @nature.com: Substrate selectivity of the human RNA m5C methyltransferase NSUN2. Read more here: buff.ly/MxxkfNf #SBGrid #ScienceMatters
Substrate selectivity of the human RNA m5C methyltransferase NSUN2 - Nature
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
buff.ly
SBGrid's eLife paper received a citation in June from Miguel Leung from the @hubrechtinstitute.bsky.social in @nature.com Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes. Read more here: buff.ly/Sl8ioMt #SBGrid #StayConnected
Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes - Nature
Structural studies of native mouse oocyte cytoplasmic lattices using cryo-electron microscopy reveal that they consist of PADI6 and subcortical maternal complex proteins plus cytoskeletal proteins,…
buff.ly
New Title Alert: CryoZeta- is a de novo macromolecular structure modeling tool that integrates cryo-EM density information with a diffusion-model-based structure prediction pipeline. More here: buff.ly/aNfL5gb #Software #SBGrid
GitHub - kiharalab/CryoZeta: CryoZeta Inference Pipeline
CryoZeta Inference Pipeline. Contribute to kiharalab/CryoZeta development by creating an account on GitHub.
buff.ly
SBGrid's eLife paper received a citation in June from Mark Lemmon from @yale.edu School of Medicine in Biochemical Journal: An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation. Read more here: buff.ly/Tn2NOTZ #SBGrid #ScienceMatters
An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation
Abstract. Muscle-Specific Kinase (MuSK) is a receptor tyrosine kinase essential for neuromuscular junction (NMJ) formation and maintenance, yet its regulation remains poorly understood.…
buff.ly
New Member Alert: John Brognard from @biochemdept-bmb.bsky.social joined SBGrid in June. Welcome!!
New Member Alert: The Structural Biology Core led by Jason De La Cruz at @mskcancercenter.bsky.social joined SBGrid in June. Welcome!!
SBGrid's eLife paper received a citation in June from @jencash.bsky.social from @ucdavis.bsky.social in the Journal of Biological Chemistry. Read more here: buff.ly/xx5KRAj #SBGrid #StayConnected
buff.ly
Community Announements: Upcoming events from our partners at @instruct-eric.bsky.social Instruct-ERIC hands-on workshop on: Advanced cryo-FIB-SEM methods Application deadline: July 1 Nov 9-13, 2026 | Heidelberg, Germany Organized by the EMBL Imaging Centre Register here: buff.ly/ejE6jyX #SBGrid
Instruct-ERIC hands-on workshop on: Advanced cryo-FIB-SEM methods (09.-13.11.2026)
EMBL Course
buff.ly
New Member Alert: Jae Yang from @stjuderesearch.bsky.social joined SBGrid in June. Welcome!!
Community Announcement: Upcoming event from our partners at @instruct-eric.bsky.social Instruct Course on Calorimetric & Spectroscopic Characterization of Biomolecules Sept 7-11, 2026 | Brno, Czechia Organized in collaboration with Anamet & Specion Register here: buff.ly/WkPtoxr #SBGrid #Collab
INSTRUCT Course on Calorimetric and Spectroscopic Characterization of Biomolecules | CEITEC - výzkumné centrum
In collaboration with Anamet and Specion we are pleased to invite you to participate in an advanced training course focused on key biophysical techniques for studying biomolecular structure,…
buff.ly
New Member Alert: Ruben Sanchez-Garcia from @ieuniversity.bsky.social joined SBGrid in June. Welcome!!
Technical Notes: June's software push includes updates to 15 titles -- AlphaFold3, AlphaPulldown, ChemEx, cryoDRGN, DeepDeWedge, EMReady2, OpenForceField Toolkit, MassiveFold, ModelAngelo, PRODIGY, PowerFit, protein-quest, Scipion, STOPGAP, and TOMOMAN. More here: buff.ly/6Pru9kY #SBGrid #Software
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
SBGrid's eLife paper received a citation in June from Craig Bingman at @uwmadisonchem.bsky.social, in Journal of Agricultural and Food Chemistry: Oxidative Characteristics of Turkey Hemoglobin A Containing Covalently Bound Epigallocatechin Gallate. Read more here: buff.ly/JL14BTw #SBGrid #Food
Oxidative Characteristics of Turkey Hemoglobin A Containing Covalently Bound Epigallocatechin Gallate
We investigated the binding of epigallocatechin gallate (EGCG) to turkey hemoglobin A (Hb), noting that polyphenols have the capacity to inhibit oxidative deterioration in muscle foods mediated by…
buff.ly
New Member Alert: Jaekyung Hyun from Sungkyunkwan University joined SBGrid in June. Welcome!!
Could Treatment Inform Prevention? bNAB-Based Vaccines For People Living with HIV: a publication in which the authors propose including people living with HIV in vaccination trials to gain a deeper understanding of the immunologic response. Read more here: buff.ly/td0DQO2 #SBGrid #HIV #Vaccines
Could Treatment Inform Prevention? bNAB-Based Vaccines For People Living with HIV
This publication highlight is part of the SBGrid Communities Project focused on science education and demonstrating how structural biology…
buff.ly
Join us July 14th for the last in this season's software webinars w/ a presentation on the Cryo-ET tools Ais & Pom from @mgflast.bsky.social of the Allegretti group @mrclmb.ac.uk. Tues, July 14, 2026 - 12:00pm ET Ais and Pom Register here: buff.ly/FxxeqqX #Webinars #SBGrid
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
New Member Alert: In June, @v-hornung.bsky.social from @lmu.de joined SBGrid. Welcome!!
Kicking Arsenic to the Curb: a paper from the labs of Douglas Reese & Bill Clemons of @caltech.edu that describe cryo-EM structure of a bacterial metalloid pump & the mechanisms that could offer more insight into ridding environments of toxic metalloids. Read more here: buff.ly/dnyw7U1 #SBGrid
Kicking Arsenic to the Curb
This publication highlight is part of the SBGrid Communities Project focused on science education and demonstrating how structural biology…
buff.ly
New Title Alert: CryoROLE- is a python package designed to analyze the particle distribution of the relative orientation between two independently refined domains of a biological complex. More here: buff.ly/aZnhqeO #SBGrid #Software
GitHub - yifancheng-ucsf/cryorole: Analyze the relative orientation landscape in multi-domains complex in Cryo-EM
Analyze the relative orientation landscape in multi-domains complex in Cryo-EM - yifancheng-ucsf/cryorole
buff.ly
Our June member tale features Dhirendra Simanshu, who spent the last 12 years building the structural biology program at the Frederick National Laboratory for Cancer Research RAS Initiative and leading research on the KRAS protein. Read more here: buff.ly/iBZ5sWC #SBGridTales #StayConnected
SBGrid Consortium - Member Tale - Dhirendra Simanshu - National Cancer Institute's RAS Initiative at Frederick National Laboratory for Cancer Research
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
New Title Alert: Germinal- is a pipeline for designing de novo antibodies against specified epitopes on target proteins. The 3-step process: hallucination based on ColabDesign, selective sequence redesign with AbMPNN, & cofolding w/ a structure prediction model. More here: buff.ly/4uEZf3w #SBGrid
GitHub - SantiagoMille/germinal: Codebase for Germinal, a broadly enabling generative pipeline for efficient generation of epitope-targeted de novo antibodies.
Codebase for Germinal, a broadly enabling generative pipeline for efficient generation of epitope-targeted de novo antibodies. - SantiagoMille/germinal
buff.ly
New Member Alert: The CryoEM Facility at @michiganstateu.bsky.social led by Sundhar Subramanianat joined SBGrid in May. Welcome!!
New Title Alert: miss-alignment- is a GPU-based tool for improving cryo-ET tilt-series alignments, designed to run from an initial eTomo/WarpTools patch-tracking alignment. More here: buff.ly/7mLXa49 #SBGrid #Software
GitHub - warpem/miss-alignment: She knows a good alignment when she sees one
She knows a good alignment when she sees one. Contribute to warpem/miss-alignment development by creating an account on GitHub.
buff.ly