Charlie Scarff
@scarfflab.bsky.social
Structural Biologist @AstburyCentre @LICAMM University of Leeds #Myosin #Muscle #Cardiomyopathy #cryoEM #MassSpectrometry Opinions my own
How mavacamten inhibits myosin to alleviate inherited heart disease revealed using cryoEM @snmcmillan.bsky.social and qXL-MS @jaimedoesxlms.bsky.social brilliant collaborative effort!! www.science.org/doi/10.1126/...
Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation
Mechanism of the myosin inhibitor mavacamten is revealed by cryo-EM and cross-linking studies.
science.org
Becoming a parent is much more detrimental to women’s academic careers than it is to men’s Read the full story: go.nature.com/4v4rxmQ
PhD studentship available - great collaborative project with @antoncalabrese.bsky.social and Prof. Sarah Harris, Sheffield
Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds, listed on FindAPhD.com
eur03.safelinks.protection.outlook.com
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com
findaphd.com
Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium! Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
nature.com
Mechanism of mavacamten inhibition of myosin - check out our preprint here: www.biorxiv.org/content/10.1...
Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin...
biorxiv.org
Having a wonderful time in Japan at the Institute for Protein Research, Osaka Uni International Conference. Fascinating and diverse protein research. Thank you!
www.findaphd.com/phds/project... Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
findaphd.com
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
findaphd.com
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
findaphd.com
www.findaphd.com/phds/project... Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
findaphd.com
4 Cheney PhD scholarships available in in situ structural biology - bench to bedside @ScienceLeeds @Astbury_BSL @LeedsBRC @LeedsMedHealth @AstburyCentre astbury.leeds.ac.uk/cheney-phd apply by 3rd December
Cheney PhD : The Astbury Centre for Structural Molecular Biology
The Cheney Scholarship 4-year PhD Scheme in in situ structural biology Applications are now invited for up to 4 new scholarships, commencing in October 2025. The application deadline is Tuesday 3rd De...
astbury.leeds.ac.uk
Do you work in the life sciences sector & are interested in "Taking drug discovery towards cells and tissue – How can this drive translation?" Join @AstburyCentre for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com
Taking drug discovery towards cells and tissues - Register interest
Join the Astbury Centre for a day focused on taking drug discovery into cells and tissues with the aim of driving translation.
astburyopeninnovation2025.eventbrite.com
Interested in how myosin generates movement? and how actin activates it? Check out our preprint: biorxiv.org/content/10.1... @UoL_LICAMM @AstburyCentre Beautiful collaborative effort!!
Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM
Myosins are essential for producing force and movement in cells through their interactions with F-actin. Generation of movement is proposed to occur through structural changes within the myosin motor ...
biorxiv.org