Scheiffele Lab
@scheiffelelab.bsky.social
neuroscientist, autism and RNA researcher, mountain lover, super dad
Here's the link to the online OA version: www.nature.com/articles/s41...
An enteric neuron ionotropic receptor regulates salt stress resistance - Nature
The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related...
nature.com
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
sciencedirect.com
Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!
Transcriptomic neuron types vary topographically in function and morphology - Nature
Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...
nature.com
Important article on the urgent question how to upkeep key information platforms for science
Science must step away from nationally managed infrastructure
Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…
thetransmitter.org
Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!
Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus
Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...
biorxiv.org
Exciting job opportunity in Europe!
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
embl.wd103.myworkdayjobs.com
Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1
Beautiful example of spatial proteomic dissection of synapse diversity from De Wit Lab!
Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...
pubmed.ncbi.nlm.nih.gov
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions. springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Neuroscience
Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...
springernature.wd3.myworkdayjobs.com
…and another cool approach to uncover RNA-RNA interactions ! www.cell.com/cell/fulltex...
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.
cell.com
Cool method! www.cell.com/neuron/fullt...
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation. Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while overexpression prevent...
cell.com
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing. www.nature.com/articles/s41...
The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
nature.com
Want a job in an exciting, science-driven environment? Genome Biology Unit Group leader call at EMBL Heidelberg: www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
embl.org
Gold nugget? www.biorxiv.org/content/10.1...
Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells
To standardize comparison of fluorescent proteins and independently determine which monomeric StayGold variant is best for live microscopy, we analyzed fluorescent protein tagged I3-01 peptides that s...
biorxiv.org
Apply for our PhD program - great rotation system and great labs! www.biozentrum.unibas.ch/phd/internat...
Biozentrum PhD Fellowships Program
The Biozentrum encourages talented, ambitious and highly motivated young scientists from all over the world to apply for the prestigious and sought after fellowships offered by the Biozentrum Basel In...
biozentrum.unibas.ch
