Mike Martynowycz
@sciencemick.bsky.social
Assistant Professor @ UB #CryoEM #FIB #MicroED
👀 The Frontiers of Structure | Science | AAAS www.science.org/content/blog...
The Frontiers of Structure
science.org
Seed to sub-Å! We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1... #StructuralBiology #CryoEM
Our latest paper is out! We combine direct electron detection and energy filtering to boost the SNR of our MicroED data This work was done at HHMI and UCLA with @sciencemick.bsky.social who now runs his own lab at UB-HWI, Johan Hattne, and Tamir Gonen www.nature.com/articles/s41...
Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications
High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...
nature.com
Our work in Nature Comms demonstrates how energy filtering, plasma FIB, and direct electron detectors in counting mode can push MicroED to sub-atomic resolution! Proud to have done this work back at UCLA. Hoping to bring similar capabilities to Buffalo. 📄 Read the paper: doi.org/10.1038/s414...
Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications
High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...
doi.org
Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.
Ardem Patapoutian@ardemp.bskyverified.social · last yr.Folks, let’s not be too quick to blame. HHMI is a progressive institution with strong leadership, doing what it can while navigating legal challenges. They get top legal advice on what’s possible, and these are tough times. Let’s not demonize one of the good ones!
I’m happy to share that @HWMRI has merged with @UBuffalo. My lab will stay at HWI, and my title is changing. I’m starting a new position as a tenure track Assistant Professor at the Jacob’s School of Medicine at the University at Buffalo!
Super happy to share our latest work! A detailed protocol for #MicroED sample prep available @NatureProtocols! It covers #FIB, grid making, sample handling, #CryoFLM, and more! Hope it helps! www.nature.com/articles/s41...
Comprehensive microcrystal electron diffraction sample preparation for cryo-EM - Nature Protocols
We present a protocol for preparing microcrystal samples for cryo-EM diffraction imaging, including room temperature solid-state small molecules and soluble and membrane protein crystals.
nature.com
‘No Way To Prevent This,’ Says Only Nation Where This Regularly Happens theonion.com/no-way-to-pr...
Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling www.nature.com/articles/s41... Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab
Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication - Nature Communications
Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus a...
nature.com