New review explores brain insulin resistance as a driver of proteinopathy in neurodegeneration; The authors provide an overview from cell-type-specific mechanisms to targeted therapeutics ( #Parkinsons gets a few mentions) link.springer.com/article/10.1...

Using structural & functional mapping, researchers report that optogenetic activation of excitatory vestibular nucleus complex neurons enhances axial movement in a #Parkinsons model www.nature.com/articles/s41...

The results of the first Australian #Parkinsons Mission trial (APM1) have been announced by Prof Simon Lewis on his website (he gets to the actual results around 28 minutes in). profsimonlewis.com/webinar-apm0...

Webinar APM001 Trial - Prof. Simon Lewis – Neurologist

Over the past 25 years, a prevailing clinical dogma has held that significant cognitive impairment constitutes a contraindication to the use of Deep Brain Stimulation in Parkinson's disease. Whilst mu...

profsimonlewis.com

If you don't follow Andy Cassy's blog posts, you really should. Some very interesting insights from a participant in the STEM-PD cell transplantation trial for #Parkinsons (and stuff about table tennis) pwap.blog

Physical activity is a modifiable lifestyle behaviour associated with lower dementia risk; Researchers have leveraged large-scale plasma proteomics to identify biological signatures of objectively monitored physical activity & cognitive ageing academic.oup.com/braincomms/a...

Researchers (led by @jeroenpasterkamp.bsky.social) demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental & adult morphologies, as well as responses to axon degeneration www.cell.com/neuron/fullt...

Studying invasive cortico-subthalamic oscillations in 22 patients with #Parkinsons during dyskinesia-evoking protocols helps researchers introduce a new state concept that may inform future adaptive neuromodulation academic.oup.com/brain/advanc...

"Neurodegenerative mortality was nearly 4x higher in NFL players [19,824 athletes] compared to the general population & remained 3x higher after accounting for competing risks"; #Parkinsons (SMR = 3.88; 95% CI: 2.76–5.30) linkinghub.elsevier.com/retrieve/pii...

New findings identify a plasma protein panel, particularly the combination of elevated IL-17C & reduced urokinase plasminogen activator, "as a robust & generalizable diagnostic signature that captures fundamental pathophysiological aspects of #Parkinsons" academic.oup.com/braincomms/a...

2026: Year of co-pathology New paper finds Aβ-positive #Parkinsons patients (n = 59; vs Aβ-negative n = 93) have more olfactory dysfunction, dysautonomia, mood disturbance, higher prevalence of RBD, hypotension & greater motor disability movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

New in-cell cryo-electron tomography research reveals differential effects of type I & type II kinase inhibitors on #Parkinsons -associated LRRK2 filament formation & microtubule association elifesciences.org/articles/111...

Researchers present PNU-120596 - an α7 nicotinic acetylcholine receptor positive allosteric modulator - which exerts anti-inflammatory and neuroprotective effects in cellular models of #Parkinsons www.sciencedirect.com/science/arti...

Using high res electron microscopy, nano-secondary ion mass spec, & energy dispersive X-ray microscpectroscopy, researchers present the elemental composition of intact neuromelanin-containing organelles was analyzed in 7 postmortem locus coeruleus samples onlinelibrary.wiley.com/doi/10.1111/...

A randomized controlled trial of 60 patients with #Parkinsons & 60 healthy controls finds 2000 IU/day of Vitamin D safely corrected nutritional deficiency in PD patients, but provided no significant short-term motor or cognitive benefits (12 wks treatment) www.ovid.com/jnls/md-jour...

Using both 2D & 3D hiPSC-neuronal models, researchers dissect the transcriptome of Parkin (PRKN)-linked #Parkinsons, revealing multiple biological processes including synaptic & metabolic function, inflammation, & intracellular trafficking www.nature.com/articles/s42...

New perspective tries to dissect divergent outcomes in stem cell-derived dopamine cell therapy trials for #Parkinsons; Comparing A9-DPC trial, Bemdaneprocel trial & Kyoto trial; "Across domains, several lessons have emerged that inform future trial design" www.cell.com/cell-stem-ce...

New editorial explores TMBIM6, suggesting that it is at the intersection between proteostasis dysregulation & #Parkinsons; Highlights recent study revealing that enhancing TMBIM6 expression in the brain is neuroprotective in models of PD www.nature.com/articles/s41...

A nested case–control study of the UK Biobank exploring pre-diagnostic factors associated with coding-based incidence of Multiple System Atrophy finds autonomic & lifestyle changes several years prior to diagnosis (mmm, rural living) movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Pre‐Diagnostic Factors Associated with Coding‐Based Incident Multiple System Atrophy: A Nested Case–Control Study of the <fc>UK</fc> Biobank

Background Multiple system atrophy (MSA) is a rare neurodegenerative synucleinopathy whose epidemiological risk factors remain poorly characterized. Objectives To characterize pre-diagnostic featur.....

movementdisorders.onlinelibrary.wiley.com

New research finds that the antiplatelet drug prasugrel mitigates neuronal apoptosis & microglial activation (via modulation of MAPK & NF-κB signaling pathways) in models of #Parkinsons www.nature.com/articles/s41...

New research results suggest a mechanism by which the #Parkinsons -associated p.G2019S mutation promotes better control of infections at the cost of excessive tissue damage via NADPH oxidase-2 activity under chronic inflammatory conditions www.nature.com/articles/s41...

The Parkinson’s disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections - Cellular & Molecular Immunology

Cellular & Molecular Immunology - The Parkinson’s disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections

nature.com

Whole-genome sequencing of 197 #Parkinsons cases reveals novel pathogenic variants in the Indian population; GBA1 & PRKN were the most frequently mutated genes www.nature.com/articles/s41...

New study reveals - in a Chinese community-based population - significant age & gender associations between sleep patterns & #Parkinsons risk; Study provides a basis for differentiated sleep interventions tailored to specific demographic groups www.nature.com/articles/s41...

People with #Parkinsons have higher serum AADC activity vs controls (even in prodromal & unmedicated stages) suggesting a process driven by dopaminergic neurodegen.; In medicated people with PD, AADC activity is markedly & dose-dependently increased www.thelancet.com/journals/ebi...

New preclinical research underscore the role of IL-6 in the inflammatory pathology of #Parkinsons & highlights sex-dependent differences www.sciencedirect.com/science/arti...

The results of the TEMPO-2 study - a phase 3, randomised, placebo-controlled, double-blind trial investigating safety, tolerability, & efficacy of flexible-dose tavapadon for #Parkinsons - have been published; Short observation period limits conclusions www.thelancet.com/journals/lan...

Safety, tolerability, and efficacy of flexible-dose tavapadon for Parkinson's disease (TEMPO-2): a phase 3, randomised, placebo-controlled, double-blind trial

Tavapadon showed significant and clinically meaningful improvements in Parkinson's disease motor symptoms, with low incidence of somnolence and impulse control disorders. However, the short observatio...

thelancet.com

Recruitment strategies in a diverse #Parkinsons cohort: Lessons from the East London PD Project; "Improving diversity in research is essential to ensure that findings reflect the populations they aim to investigate" neurologyopen.bmj.com/content/8/2/...

A large-scale, multi-ancestry genetic study offers crucial insights into the population-specific genetic architecture of #Parkinsons; "increased ancestral diversity in PD research will be crucial" & ensure equitable access to emerging therapies. #GP2 www.thelancet.com/journals/lan...

New review explores #Parkinsons as a multi-axis systems disorder; "Single-target therapies have shown limited disease-modifying effects, suggesting that interventions aimed at individual molecular pathways may be insufficient" link.springer.com/article/10.1...

A systematic review of movement sensors explores the monitoring of nocturnal movement & sleep in #Parkinsons; "Comparing wearable & polysomnography parameters show that actigraphy can accurately estimate sleep parameters for individual PwPD" www.nature.com/articles/s41...

A systematic review & meta-analysis links long-term PM2.5 and PM10 exposure to #Parkinsons, but not #multiplesclerosis; Could outdoor air pollution be a potential modifiable neurodegenerative risk factor? The evidence is accumulating www.sciencedirect.com/science/arti...