DAWells

@sciencewells.bsky.social

I'm a biologist and a programmer 🦭🧬🦠. I want to encourage people to use code and open data to ask questions of the natural world just for fun! He/him dawells.github.io

A mutation in a strain of measles allowed it to go undetected by common targeted sequencing surveillance 🧬. The assay has now been updated to detect the mutant 🖥️. Targeted sequencing is incredibly sensitive but it must be supported by genomic surveillance to keep the targets up to date 🧪🦠

During London tube strikes, commuters had to change their underground route 🚇. 5% preferred their new route and kept using it after the strikes were over. What changes have you kept after forced exploration?

Slow growing bacterial infections are not just a challenge for id and culture. Their slow growth also makes treatment slower. Mycobacterium malmoense 🦠 takes 2 months to grow on a plate and 2 years of antibiotics to treat. 🧪

For students who look to LLMs for help with their code but run into usage limits, running an open-weight LLM locally doesn't use up that much storage space and may have similar latency as cloud solutions -- and easy to connect to Positron, VSCode, and others. www.xda-developers.com/self-hosting...

I started self-hosting an LLM, and it became my favorite productivity tool

I installed a local LLM for privacy, but the biggest surprise was how much faster it made my daily workflow.

xda-developers.com

New Zealand has become the last place to detect 2.3.4.4b bird flu (high pathogenicity H5N1). After even Antarctica (2023). 🧪 It's a worry for their native birds, but they've been proactively preparing by vaccinating endangered birds. 💉🦜

Delighted to share some good news 🧪 “This hugely encouraging news shows the life-saving impact of the HPV vaccine, and it’s incredibly exciting to be able to say to this whole generation: cervical cancer shouldn’t be a risk for you,” says Caroline Temmink www.newscientist.com/article/2530...

No young women have died of cervical cancer in England for years

We already know the vaccine against human papillomavirus, or HPV, greatly reduces infections and cases of cervical cancer, and now we have the first evidence it prevents deaths too

newscientist.com

Hantaviruses use "cap snatching" to start reading instructions from their genome. They cut up host mRNA and use that as primers for their own transcription. You can see this in their transcripts because they start with unrelated fragments of host sequence 🧪🧬🦠

I recently learnt that muntjac deer are native to South East Asia. At the start of the 1900s a handful escaped from a private collection at Woburn Abbey. Despite this population bottleneck, there are now over 100,000 in the UK

Bild

India’s genomic map reveals ~130M variants—many previously unknown. Strong population structure + rare, population-specific variants expose limits of Eurocentric datasets. Precision medicine needs diversity, not assumptions. #Genomics #PrecisionMedicine #HumanDiversity tinyurl.com/3mverx3p

India’s DNA map uncovers millions of missing genetic variants

A vast study reveals deep diversity, hidden disease risks and exposes the limits of Eurocentric medicine.

tinyurl.com

Very happy to say that the 🧬 🖥️ tool HLAfreq is now published doi.org/10.21105/joss.10122 Use it to combine HLA allele frequency datasets. I made it to help vaccine design but love seeing it put to other uses. Let me know if it's useful to you! 🧪 #hlafreq

HLAfreq: Download and combine HLA allele frequency data

Wells et al., (2026). HLAfreq: Download and combine HLA allele frequency data. Journal of Open Source Software, 11(121), 10122, https://doi.org/10.21105/joss.10122

doi.org

The USDA phonological watercolors are a collection of beautiful botanical illustrations I've been admiring. Exploring then was made much easier thanks to pomological.art/. Are there any similar collections of animal scientific illustrations you'd recommend? #sciart

USDA Pomological Watercolor Collection

Explore over 7,500 historical watercolor paintings of fruits and vegetables from the USDA Pomological Collection, featuring rare varieties from 1886-1942.

pomological.art

Scientists have confirmed that group A strep can be identified in ancient remains. They found pathogen DNA in a prehispanic mummy from Bolivia — raising the question: Where did strep (and diseases like scarlet fever) originate? 🧪🏺

700-year-old mummy from Bolivia contains earliest confirmed evidence of strep throat bacteria in the Americas

A DNA analysis of pathogens from a pre-Hispanic mummy revealed that the bacterium that causes scarlet fever and strep throat was present in the Americas prior to European colonization.

livescience.com