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Selma M.

@selmamhm.bsky.social

PharmD; PhD Postdoc at NorthwesternU Chicago - Former Pasteurienne - Betrayed Salmonella for Neisseria

6 Posts86 Follower140 Folgt
Selma M.@selmamhm.bsky.social · last mo.

Back-to-back papers! Following our recent work on Restriction-modification systems in 𝘕𝘦𝘪𝘴𝘴𝘦𝘳𝘪𝘢 𝘨𝘰𝘯𝘰𝘳𝘳𝘩𝘰𝘦𝘢𝘦, we now show that targeting type I CRISPRi to the leading strand of the 𝘨𝘢𝘳 R-loop/G-quadruplex region upstream 𝘱𝘪𝘭𝘌 restores pilin antigenic variation in a G4-locked strain or a 𝘨𝘢𝘳 mutant.

Gc Rox@gcrox.bsky.social · last mo.

@selmamhm.bsky.social Shows how a Type I CRISPRi module targeted to the leading strand can replace the actions of a guanine quadruplex and small RNA R-loop in Neisseria pilin antigenic variation. doi.org/10.1128/mbio... #evolution #mevoSky #evoSky #microSky #scienceSky

Gc Rox@gcrox.bsky.social · last mo.

Are restriction/modification modules only used for host defense? @selmamhm.bsky.social shows an alternative use. "Restriction-modification systems are required for Neisseria gonorrhoeae pilin antigenic variation" www.pnas.org/doi/10.1073/pnas.2602688123 #Microd #Microsky. #Microbiology

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Kai Kupferschmidt@kakape.bsky.social · 8mo ago

And there it is: FDA has approved zoliflodacin for gonorrhea as well. That makes two new antibiotics to treat this STI and it means a fascinating debate now about how to use these drugs in a way that will delay resistance as much as possible… 🧪 #IDsky

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Gc Rox@gcrox.bsky.social · 8mo ago

Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants url: academic.oup.com/jid/article/... @iboiko.bsky.social and Selma Metanne

Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants

Most Neisseria gonorrhoeae clinical isolates are piliated but lose piliation during laboratory passage. However, most public genomic sequences are from non

academic.oup.com

Gc Rox@gcrox.bsky.social · 9mo ago

A new article by @husonfirst.bsky.social about Neisseria Flavin pathways and pilus phenotypes : dx.plos.org/10.1371/jour...

Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing

Author summary Neisseria gonorrhoeae is the causative agent of the sexually transmitted disease, gonorrhea. Neutrophils are first host immune responders that activate multiple potent antimicrobial def...

dx.plos.org

Gc Rox@gcrox.bsky.social · 10mo ago

Microbiology Postdoctoral Position (Please re-post) A funded postdoctoral position in Chicago will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. If interested, please get in touch with Hank Seifert h-seifert@northwestern.edu

Géraldine Laloux@lalouxlab.bsky.social · last yr.

We wrote 2 📕 chapters with tips & tricks to identify protein-protein interactions in bacteria 🦠 1) In vivo proximity labeling with miniTurbo link.springer.com/protocol/10.... 2) An adapted polar recruitment assay feat. E. coli as a test tube link.springer.com/protocol/10..... Enjoy #MicroSky 🧪

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