Tke5: A new weapon against crop-killing bacteria! 🌾⚠️ This toxin kills harmful plant pathogens by forming pores in their membranes. 🦠 #SEVA ⭕ allowed controlling its expression safely during the study. Read more: shre.ink/31qa

PlasmidGPT 🤖 A new step for plasmid design If we combine data-driven modeling with standardized engineering practices, we can make biological design more intuitive, efficient, and expansive. Read the paper👉 shre.ink/31bJ #SEVAplasmids #SynBio #Standardization #GenomeEngineering

A SEVA plasmid name ⭕ can tell you all you need to know. Just read the code: 🔹Selection marker 🔹Replication module 🔹Cargo 🔹Additional gadgets Standards make life easier. Learn more about nomenclature 👉https://acortar.link/XZmJVZ

An automated workflow for high-precision genotyping of transposon variants with minimal manual intervention 🚫🤲🏼 Once again, #SEVA⭕✨steps forward to assure scalability and reproducibility for the #SynBio community. Read the study here 👉 bit.ly/4vAkSAb

Generative AI is changing synthetic biology 🧬🤖 with an immense potential for plasmid design⭕ The era of precision design is just around the corner⚙️✨ Read more here 👉 bit.ly/4uqPxz1

SEVA’s ⭕ LEGO style! Build your plasmid: 1️⃣ Pick a Marker. 2️⃣ Select an Origin. 3️⃣ Snap in a Gadget. 4️⃣ Add the Cargo. Start: 👉 acortar.link/G9uSJA

Pooled rAAV libraries might be noisier than we think! This study reveals that packaging recombinant AAV libraries as a pool leads to extensive chimerism due to "barcode swapping" 🧬🔀🧬 At #SEVA ⭕, we believe that standardisation can be a good strategy to prevent this. Read here 👉 doi.org/q42d

Rare codons slowing down your protein expression? 🛑 pCODE plasmids are an elegant solution to rescue recombinant protein production by overexpressing tRNAs! ✨ Proudly, #SEVAplasmids⭕ were used to design this new system. Check out 👉 doi.org/q42c

🧬 Balancing genes in one cell has always been a great challenge! 🧑‍🔬 This review shows the shift from simple co-expression setups to more complex systems. It highlights the contribution of #SEVA⭕✨ as a key step toward modular, programmable designs. Read here👉 doi.org/q4z9

🧑‍🔬 "The question is no longer whether labs can automate, but how far they should go". A recent article in R&D World magazine discusses the future of laboratory work and the impact of AI. 👉

A new roadmap for automation in synthetic biology

The building blocks for the autonomous lab exist, and a new framework published in SLAS Technology outlines how to get there.

rdworldonline.com

🧑‍🔬Easy to design, easy to order, free of charge… It sounds like a dream, but it is not! In SEVA plasmids we want you to be able to get the exact plasmid you need, so we created an open designing platform to create your own! Try it our yourself!👉

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com

🤔The ins and outs of membrane fusion, as told by experts from the University of Genova and Max Planck Institute. This last review brings together insights on the impact of lipid composition, environmental conditions, and fusogenic agents on this essential biological process👉 doi.org/10.1080/2374...

🧑‍🔧⭕Let’s dissect a SEVA plasmid! Built on a modular architecture, our plasmids make it easier to identify key vector elements. 🧬Origin of replication: more then 15 types 🔆Cargo region: such as cloning or CRSIPR. 💊Antibiotic marker: choose it from out of 10 possibilities. 👉 shorturl.at/04ZtK

FIND YOUR PLASMID - SEVA plasmids - Standard European Vector Architecture

Canonical SEVA plasmids that use Golden Gate assembly to build complex genetic circuits. Find your canonical plasmid In the dropdown menu below, you can select a combination of choice for your…

seva-plasmids.com

Better vector design can make all the difference 🔬 Researchers examined how plasmid vectors are optimized for gene editing and genetic engineering. They focused on 🔧function 📈efficiency 🔀and versatility in #biotech applications Just how SEVA likes it.👉 Read their insights here: doi.org/qz47

Plasmid vectors for gene editing and genetic engineering: Design principles, efficiency, and applications

Plasmid vectors remain central to gene editing and genetic engineering, providing flexible, modular, and cost-effective platforms for genome manipulation across microbial, plant, and eukaryotic…

doi.org

Designing plasmids shouldn’t be blocking your experiment 🧬 ⭕SEVA plasmids provide a shared framework for vector construction, helping researchers work with greater flexibility and #reproducibility in biotechnology and microbial engineering. Explore our website👉

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com

🔬New model systems are helping reshape drug discovery. Nowadays there are more relevant ways to study disease biology, and improve early-stage screening. TheScientist has reviewed the latest advances in this new guide about how to use in vitro models 👉https://shorturl.at/DXbIg

Methanol as feedstock? Maybe not for us but… 🧪 Resarchers built new biology toolkit to help microbes grow using methanol, making them easier to engineer and more stable. 👉Read how they managed to do it:

A synthetic biology toolkit for the plasmid-dependent and thermophilic methylotroph Bacillus methanolicus

Bacillus methanolicus, a unique plasmid-dependent and thermophilic methylotroph, is an ideal chassis for one-carbon (C1) biomanufacturing. Despite its…

doi.org

👩‍🔬 The #SEVA collection keeps growing thanks to community contributions. Add your constructs to our open plasmid repository and help improve reproducibility in #SynBio. ✨ Check the guidelines and join our mission 👉

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com

🔬Tired of replicating that experiment and getting different results? SEVA simplifies #SynBio with a universal vector system! All SEVA #plasmids follow a standardised format. Reproducibility starts here! ⚙️👉

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com

🧬🖨️ Boosting 3D-printed tissues! MIT engineers have developed a compact magnetic mixer that keeps bioinks uniformly mixed during printing. This makes engineered tissues more reproducible and scalable – just like SEVA likes it! Check the whole story👉

Magnetic mixer improves 3D bioprinting

A new approach developed at MIT aims to solve a core limitation in 3D bioprinting, by actively preventing cell sedimentation within bioinks, allowing for more reliable and biologically consistent 3D…

surl.li

🔭New plasmids on the horizon! Scientists from @bfrde.bsky.social detected megaplasmids in enteropathogenic Vibrio spp. These have 80% unclassified genes! ⭕What’s more, the megaplasmids suggest a non-Vibrio origin 👉

💪An easy way to gain glucose! Scientists have developed a plasmid-free and inducer-free Escherichia coli to produce glucose. This may be an interesting way of reducing expenses💸. Read how they could do it👉

🛠️✨We are the Standard European Vector Architecture (SEVA), a web-based resource in which you can choose the #plasmid that you need for your research. Our goal is to make #reproducibility, a reality. Check them out 👉

Find your plasmid

Canonical SEVA plasmids that use Golden Gate assembly to build complex genetic circuits. Find your canonical plasmid In the dropdown menu below, you can select a combination of choice for your canonical...

seva-plasmids.com

🔬SEVA format involves a set of rules to unify the scientific community. These are visible in our #plasmid nomenclature. By order: 🦠 Antibiotic resistance marker ⭕ Origin of replication 📦 Cargo module 🛠️ Optional gadgets Learn how it works here 👉https://shorturl.at/V5ff1

BACKBONE MODULES & NOMENCLATURE - SEVA plasmids - Standard European Vector Architecture

Plasmid Backbone The colored arrows above the cargo and AbR modules represent the directionality of the transcription flow of that element SEVA Plasmid Nomenclature The figure sketches the expanded…

seva-plasmids.com

Using photosynthesis as a work chain ☀️ Researchers aimed to engineer cells that can capture light and use it to produce valuable compounds. 🦠They successfully reprogrammed E. coli to perform efficient photobiosynthesis of several products! 👉

Light-driven metabolic makeover

New-to-nature photometabolisms are highly intriguing for manufacturing but difficult to achieve. Now, Escherichia coli engineering integrates flavin-based photobiocatalysis with natural enzymatic reactions,...

doi.org

⭕❌What would happen if organisms with and without plasmids compete? I will give you a hint: this plasmid-bearing population can produce an allelopathic toxin that is lethal to its plasmid-free competitor, and yet, who wins?👉

Mortality can induce limit cycles in a chemostat competition model between plasmid-bearing and plasmid-free organisms with allelopathy - Computational and Applied Mathematics

In this paper, we study a model of competition between plasmid-bearing and plasmid-free organisms in a chemostat, where the plasmid-bearing population produces an allelopathic toxin that is lethal to…

doi.org

⭕✨Standard, tailor-made, and send directly to your door food free. Too good can be true. Take a look at our website and check our vectors free of charge 👉

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com

🦠✨This bacterium can act as a “sickness traffic light”. @ctropini.bsky.social and her group from the University of British Columbia have engineered a system in which cells that normally produce GFP reduce their fluorescence under stress conditions. Discover the full story 👉https://shorturl.at/f9bpu

❓🦠With N, what is the main cause of foodborne illness? Non-typhoidal Salmonella! In it, plasmids enhance adaptability, combining resistance and virulence. Microbiota-targeted or CRISPR-based tools can provide opportunities to disrupt plasmid dissemination. 👉Check how:

Science anywhere? Absolutely yes! Science anyhow? No please! The #SEVA database of vector plasmids aims to improve Science replication and create a world in which high-quality science is available no matter where. Join us! 👉 seva-plasmids.com

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…

seva-plasmids.com