SPy is my new favorite "fast python" variant. The key insight is that almost all of the dynamic nature of Python is useful at import time, not run time: your metaclasses, dynamically generated methods etc, all the magic happens at import time. So you can freeze before runtime!
Join Antonio Cuni at EuroPython for "SPy: high-level Python, low-level performance, no overhead" ep2026.europython.eu/FRFEHE