Huge congratulations to our fellow researcher @minoo-matbouriahi.bsky.social on her latest publication in JAMA Network Open! She teamed up with @floriannaudet.bsky.social John Ioannidis @ioanaacristea.bsky.social, and a stellar team to tackle a fascinating topic in #ResearchIntegrity #PeerOnSky

- Green: ResToRes : Cédric Lemarchand - Orange : OSIRIS : @constantvinatier.bsky.social - Purple : @sharectd.bsky.social : @giulia-varvar.bsky.social and @kahin-tai.bsky.social - Red : Former member of the team, now in iRISE_EU : Laura Caquelin ... and me ;)

Big news! 🚀 We are thrilled to announce that our first joint publication by 11 SHARE-CTD doctoral students is officially out in @springernature.com "Supporting the Reanalysis and Reuse of Clinical Trial Data: a case study" This paper is the fruit of our very first Datathon in Göttingen. 🧵

Yesterday was the last day of our @sharectd.bsky.social Datathon 2 in Utrecth. Over the 1 week, 3 independent teams worked on the same research question: “Does esketamine have an impact on suicidality?”, using the same individual patient data shared by Johnson & Johnson on the The YODA repository.

Hi #ScienceSky people, back with #PeerOnSky series! After discussing reporting bias, let’s dive into a topic that’s currently reshaping regulatory landscapes and drug development: External Controlled Trials (ECT). Ever heard of "Synthetic Controls" or "Historical Controls"? Let’s break it down!

This paper is fully aligned with the themes of our @sharectd.bsky.social doctoral network featuring stellar PhD students (such as @kahin-tai.bsky.social and @giulia-varvar.bsky.social with whom we have published several nice papers on data sharing). a) www.jclinepi.com/article/S089...

Reusing clinical trial data to consolidate and advance medical knowledge

While data sharing holds great potential to maximize the value of research and reduce waste, these benefits can only be fully realized if shared data are also effectively reused. Yet, data reuse remai...

jclinepi.com

@kahin-tai.bsky.social's excellent talk (delivered as part of the LORIER Webinar Series on Reproducibility and Meta-Research, in partnership with @sharectd.bsky.social, ResToRes Research integrity in biomedical research, OSIRIS, the @reproductible-fr.bsky.social and Embrace) is now online.

Over the coming days, three independent teams (@sharectd.bsky.social PhD students + clinical & statistical experts) will each conduct their own IPD meta-analysis to answer the same research question. 👉 Can esketamine reduce suicidality?

Stay tuned... I’ll share updates during the week. And @sharectd.bsky.social website is here : www.sharectd.eu

Long time no see, #ScienceSky people! 👋 After a short hiatus, we're reliving the #PeerOnSky series. A "silent" issue in clinical trials: Outcome Reporting Bias (ORB). Let's revisit a classic but vital paper by Smyth et al. (2010) that gets into the heads of trialists. www.bmj.com/content/342/...

Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists

Objectives To provide information on the frequency and reasons for outcome reporting bias in clinical trials. Design Trial protocols were compared with subsequent publication(s) to identify any discr...

bmj.com

#PeerOnSky Article 2! "Meta-analysis of individual participant data: rationale, conduct, and reporting" by Riley et al. (2010). IPD boosts power for subgroups and adjusts for confounders. Read: doi.org/10.1136/bmj.... What challenges do you face in IPD meta-analyses? #OpenScience #MetaAnalysis

Meta-analysis of individual participant data: rationale, conduct, and reporting

The use of individual participant data instead of aggregate data in meta-analyses has many potential advantages, both statistically and clinically. Richard D Riley and colleagues describe the rational...

doi.org

A must read work from our network. 👍

Florian Naudet@floriannaudet.bsky.social · 11mo ago

"A New Hope: SHARE-CTD trilogy concludes with data reuse" The @sharectd.bsky.social project concludes its "trilogy" with a guide to clinical trial data reuse. In this chapter, @giulia-varvar.bsky.social introduces principles to support effective data reuse. restores.univ-rennes.fr/highlights/n...

🔬 #PeerOnSky starts! “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” by Mello et al. (2018). They found participants value data sharing for science, but worry about privacy breaches. A 2018 perspective still relevant today! Does this reflect current views? #DataEthics

🎉 Hello all! Welcome to #PeerOnSky! It stands as 'Peer discussion on the Sky'. We will dive into cutting-edge research, sparking discussion on BlueSky using the articles discussed within our network. We’ll kick off with a 2018 gem on clinical trial data sharing. #OpenScience #Research #JournalClub

a must read article for the week!

Florian Naudet@floriannaudet.bsky.social · 12mo ago

New paper in @jclinepi.bsky.social led by my super cool PhD student @kahin-tai.bsky.social with the SHARE-CTD (@sharectd.bsky.social) crew. It is the 2nd paper in a “JCE trilogy” on data sharing by SHARE-CTD: the 1st one addressed the topic in broad terms, and the third will focus on data reuse.

🌧️ Just wrapped Datathon1 at UMC Göttingen, from 07 to 11 July! Part of SHARE-CTD, this in-person event brought doctoral students, PIs, and lecturers together for clinical trials, biostats, and data mgmt. Check the Vibes! #SHARECTD #Datathon #Research #biostatistics

💬 Participants deserve to know! This Trials paper (doi.org/10.1186/s130...) pushes for sharing clinical trial results with participants—because their contributions matter. From a patient’s view, it’s about respect & transparency. Let’s dive in! #ClinicalTrials #Transparency #ShareCTD

Sharing clinical trial results with participants: important, expected and possible - Trials

Participants in clinical trials should be pro-actively offered the results of trials in which they have participated. This should be done in a way that is accessible and understandable for all partici...

doi.org

🔬 New paper alert! BMC study (doi.org/10.1186/s128...) proposes 6 solutions target ethics, registries, & governance to tackles Germany’s clinical data sharing crisis. Only 2% of medical research shares data—time for change! Read on! #OpenScience #DataSharing #ShareCTD

🔍 Fascinating read! This PLOS Biology paper uncovers misuse of the NHANES dataset by potential paper mills—raising red flags on shared data integrity. Not about trials, but a must-discuss for research ethics. Check it: journals.plos.org/plosbiology/... #ResearchEthics #DataIntegrity #OpenScience

Explosion of formulaic research articles, including inappropriate study designs and false discoveries, based on the NHANES US national health database

The combination of AI and national health databases offers opportunities, but may also be exploited by unethical agents. This study shows that there has been an explosion of formulaic research article...

journals.plos.org

🎉 Today’s the day! ICTD 2025 - Rethinking Clinical Trials: Inclusivity in Practice, co-hosted by ECRIN @ecrin.bsky.social & SCReN in Madrid. How do we turn talk into action for inclusive study design? Tune in online—registration & waitlist are full! ecrin.org/ictd-2025 #ICTD2025 #ClinicalTrials

🎉 Big news for clinical research! SPIRIT2025 just dropped, adding an Open Science section & a new Item No. 6 on data sharing. This pushes transparency in trials—where & how de-identified data, code, & materials will be accessible. Check it: www.consort-spirit.org #OpenScience #ClinicalTrials

🎉 Kudos to Giulia @giulia-varvar.bsky.social for her speed talk at "Printemps de la Recherche" last Tuesday! She presented about SHARE-CTD, and her project on re-analysis of pivotal trials in Oncology, to Irset’s 350+ pros. A great moment to showcase open science in medicine!🔬 #SHARECTD #OpenScience

🙌 Big props to our SHARE-CTD scientist featured in STAT News! His insights on boosting clinical trial transparency in France (only 57% results shared, 2012-2022) are key to open science. 🔬 #SHARECTD #OpenScience #ClinicalTrials #DataSharing

Florian Naudet@floriannaudet.bsky.social · last yr.

"French trial sponsors are urged to bolster clinical trial transparency": STAT News covers the recent French report urging that study results be published in a registry. I was very happy to be interviewed and provide some context.

For those of you who are interesed, please join and register

Florian Naudet@floriannaudet.bsky.social · last yr.

In partnership with RestoRes and Embrace, LORIER’s monthly webinars address key issues for reproducible health research, including data sharing, reproducibility, and meta-research. This series, starting in June 2025, features international experts. restores.univ-rennes.fr/highlights/l...

💬 We want to hear from YOU. Are you a: 👨‍🔬 Researcher? 👩‍⚕️ Clinician? 🧑‍💼 Policymaker? 🤔 Just curious? This space is for discussing how data sharing can shape better healthcare. We’ll keep you posted right here on Bluesky. Follow us to stay involved. Let’s share! #ScienceCommunication #DataSharing

🔍 What is SHARE-CTD? We’re a Marie Skłodowska-Curie Action (MSCA) doctoral network funded by the EU. Our mission? To train future experts in clinical trial data sharing, from regulation to ethics to advanced data science. #ClinicalTrials #ResearchTraining #DoctoralNetwork

Welcome to the official Bluesky account of SHARE-CTD! We're a European research network dedicated to enhancing clinical trial data sharing to advance medical research and the betterment of society. Learn more: share-ctd.eu #SHARECTD #OpenScience #DataSharing

NEWS

New article "The validation of prediction models deserves more recognition" published in BMC Medicine 2025.03.24 Begüm Irmak Ön and Ulrich M…

share-ctd.eu