Research reveals that p53 is crucial for safely reprogramming human somatic cells to pluripotency, balancing efficiency and genomic stability against oncogenes, like Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA 🧪

A phytoscreen of 43 fruits & veggies identified garlic as a powerful deterrent of mating & egg laying in Drosophila. Diallyl disulfide effectively inhibits these behaviors! 🍃🦟 PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG 🧪

New study reveals E3 ligase MARCH7 as a key ferro-guardian, regulating iron homeostasis and suppressing ferroptosis by ubiquitylating NCOA4 at K42! PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) facilitates the export of large transcripts in muscle cells, revealing a crucial role during myoblast differentiation into myotubes. This novel pathway enhances understanding of… PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7

Transposable elements (TEs) make up nearly 50% of mammalian genomes, influencing gene expression and evolution. Recent studies reveal that even non-mobile TEs can regulate genes at specific loci. Insightful… PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9

Heat stress in mice led to increased metabolic dysfunction when later fed an obesogenic diet. Key findings show skin-derived KLK14 affects hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a vital cancer therapy, induces neurotoxicity by triggering NER-mediated neuronal death. Unlike in dividing cells, NER promotes vulnerability in neurons, revealing new therapeutic targets. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky 🧪

Xenophagocytosis blocks efficient xenogeneic donor cell engraftment in livestock for organ creation. Targeting elevated phosphatidylserine boosts interspecies chimerism. PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AAN-I-IFNs+ patients with severe COVID-19 show a diverse B cell response against type-I IFNs, similar to those with genetic T cell tolerance defects, highlighting a key autoimmune mechanism. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky 🧪

B cells enhance exercise capacity by secreting TGF-β1, reprogramming liver glutamine metabolism via GLS2 and SLC7A5, preserving muscle glutamate for ATP production. PMID:42208497, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00513-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, enhancing predictions of cell fate by identifying key regulators. #RNAvelocity #RegVelo PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mouse olfactory system mapped using MERFISH reveals distinct patterns in olfactory receptor (OR) expression, crucial for detecting odors related to food and social interactions. Key findings show systematic… PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2

A study reveals that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) gene program, reshaping development processes in 3D for tumor expansion. Key insights show how cellular… PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X

New findings reveal that lung adenocarcinoma (LUAD) boosts nociceptive innervation, leading to elevated CGRP levels that hinder CXCL13+ fibroblast recruitment and limit tertiary lymphoid structures (TLS)… PMID:42161272, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00505-2 #RNA 🧪

A groundbreaking study maps cellular senescence across human tissues, identifying diverse senotypes through single-cell multi-omics and AI. Key insights reveal tissue-specific programs and interactions, paving… PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8

Study reveals TPPP/p25 in CSF as a specific biomarker for multiple system atrophy (MSA), outperforming α-synuclein in distinguishing synucleinopathies. PMID:42190663, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00517-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

SAMENT reveals that bone metastatic niches exhibit 3 key features: 1) macrophage enrichment, 2) T cell depletion, and 3) organ-specific heterogeneity across cancer models. PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New spatial CRISPR screen sequencing (SPAC-seq) links gene perturbations to spatial phenotypes. TARDIS aids in prioritizing targets, enhancing 5 key pathways to improve tissue-level biology insights. PMID:42190664, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00516-7 #Medsky 🧪

~50% of fertilized eggs arrest during human pre-implantation development. Key findings reveal second mitotic divisions are most error-prone; centriole overduplication can be suppressed with PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9

A novel gene switch activated by electromagnetic fields (EMFs) enables precise control of gene expression in vivo. Identified through a CRISPR-Cas9 screen, Cyb5b acts as a crucial EMF sensor, enhancing… PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #RNA 🧪

A novel non-invasive genetic system traces neuron-derived protein clearance, revealing distinct drainage routes & hotspots bypassed by standard tracers in brain-CSF dynamics. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered ADAR-recruiting RNAs (arRNAs) enhance RNA editing via endogenous ADARs. LEAPER 3.0 integrates AlphaFold 3 for precise, efficient editing, advancing arRNA design! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo integrates splicing kinetics with gene regulatory interactions, enhancing RNA velocity models. This breakthrough offers deeper insight into cell fate transitions and dynamics. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA 🧪

A study on 311 brain samples reveals >1,000% enrichment of somatic SNVs in cancer driver genes in Alzheimer's, linked to clonal hematopoiesis and expansion in microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Cryo-EM reveals Wnt3a/Fzd8/LRP6 complexes in a 2:4:2 arrangement, showing how Wnt simultaneously binds to Frizzled and LRP5/6, crucial for Wnt/β-catenin signaling. PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ErbB receptor dimerization is essential for activation. Long-term single-molecule imaging reveals oncogenic EGFR mutations lead to stable, ligand-independent dimers, reshaping understanding of receptor dynamics. PMID:42054992, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00399-5

Replaying 100+ monoclonal germinal center reactions reveals how B cell competition drives antibody affinity evolution, showcasing the dynamics of affinity maturation. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Acute SARS-CoV-2 triggers diverse autoantibodies (AABs) that persist in long COVID (LC). Higher AABs targeting CNS and PNS proteins correlate with neurocognitive symptoms. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking D&D-seq reveals single-cell DNA-protein interactions, overcoming weak affinity mapping challenges. Insights show TF binding shapes gene expression dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleogenomes reveal 12 cave lion genomes spanning >100,000 years show distinct evolutionary lineages from modern lions, with unique variants and ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪