Siavash
@siavashk.bsky.social
UCLA faculty; interested in histones, metabolism, and soccer.
Thank you for all the support! I look forward to contributing to the success of ASBMB and our broader community.
American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · last yr.Sharing the news with newly elected leaders who are on Bluesky! • Congratulations to @siavashk.bsky.social & @christinedunham.bsky.social.
New paper out! 📢 We show that amino acid restriction triggers genome-wide H4K20me1 loss and MYC activation—priming cells for rapid protein synthesis upon refeeding. A chromatin-based strategy for surviving nutrient stress with implications for MYC-driven cancers.
Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restriction - Cancer & Metabolism
Background Cells adapt to nutrient fluctuations through both signaling and epigenetic mechanisms. While amino acid (AA) deprivation is known to suppress protein synthesis via mTORC1 inactivation, the ...
cancerandmetabolism.biomedcentral.com
If you’ve struggled making a creamy Cacio e Pepe sauce, science is here to help you! pubs.aip.org/aip/pof/arti...
Phase behavior of Cacio e Pepe sauce
“Pasta alla Cacio e pepe” is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect
pubs.aip.org
I’m not sure science was the best choice of career… www.biorxiv.org/content/10.1...
Face photo-based age acceleration predicts all-cause mortality and differs among occupations
While scientists argue what aging is and what drives aging, it is widely accepted that our face changes drastically with age and that mortality increases in late life. We hypothesize that people of th...
biorxiv.org
Learn about the remarkable life and career of Sabeeha Merchant, an incredible scientist who was my biochem teacher as an undergrad and is now an invaluable mentor and collaborator. www.sciencedirect.com/science/arti...
The Elements of Life, Photosynthesis and Genomics
I am a Professor of Biochemistry, Biophysics and Structural Biology and Plant and Microbial Biology at the University of California in Berkeley. I was…
sciencedirect.com
Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects. www.science.org/doi/10.1126/...
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.
science.org