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Sijbren Kramer

@sijbren-kramer.bsky.social

Avian flu threatens global health and agriculture, with pandemic potential☣️ if it spreads between humans😷. To enable surveillance, we developed 3 CRISPR-based assays for rapid subtype- and clade-specific detection of avian influenza in low-resource settings.⬇️ (1/11) www.medrxiv.org/content/10.1...

Streamlined CRISPR-based assays for detection and subtyping of avian influenza

Avian influenza viruses (AIVs) are zoonotic pathogens that pose an increasing global threat due to their potential for human-to-human transmission, pandemic emergence and significant economic losses i...

medrxiv.org

Sijbren Kramer @sijbren-kramer.bsky.social · last yr.

Multiplexed nucleic acid detection is critical for the surveillance of pathogens and mutations, but existing technologies either require extensive lab equipment or have low multiplexing. We built a portable microfluidic manifold for massively multiplexed CRISPR-based detection. (1/12)

A handheld microfluidic manifold for massively multiplexed CRISPR-based nucleic acid detection

Multiplexed methods for nucleic acid detection are immensely challenging to deploy outside of laboratory settings. Conversely, field-deployable methods are limited to low levels of multiplexing. Durin...

biorxiv.org