A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor Maroschek et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Simon Snoeck
@simonsnoeck.bsky.social
Postdoctoral researcher at the Zipfel lab. Plant immunity, transmembrane receptors and phytocytokines. Latest research: rdcu.be/eTOhF https://doi.org/10.1073/pnas.2400862121 Latest review: https://rdcu.be/dZPdL
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network https://www.biorxiv.org/content/10.64898/2026.05.18.725810v1
A new "LORE" paper is out from Ranf lab at TUM in Germany and University of Fribourg in Switzerland: www.biorxiv.org/content/10.6... Fatty acid-sensing receptors were previously only described in Arabidopsis. Do they function the same way in other plants?
biorxiv.org
Much like the Island Domain shifting its shape, our preprint has transformed too @natcomms.nature.com rdcu.be/eTOhF
β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling
Nature Communications - Using AI-based structural modeling, the authors reveal the ligand-binding and subsequent receptor complex formation mechanisms of three LRR-RP-type plant PRRs and propose a...
rdcu.be
By the @cellsensing.bsky.social and Zipfel labs: The plant receptor kinase HSL3 senses a cyclic, disulfide-bond stabilized peptide phytocytokine. www.biorxiv.org/content/10.1...
Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. www.biorxiv.org/content/10.1...
Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
science.org
MIK2 clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families https://www.biorxiv.org/content/10.1101/2025.05.22.655486v1