If you’ve built DNA-barcoded antibody panels, you know the pain: every barcode means another conjugation. In our new preprint we introduce UnO, which transforms antibody conjugation problem into a universal barcode conversion workflow, enabling rapid panel generation. www.biorxiv.org/content/10.6...

Universal oligo adapters for high-efficiency DNA-barcoded antibody panel generation

DNA-barcoded antibodies are central to a broad range of spatial and dissociative assays and applications, including multiplexed imaging, single-cell profiling, and proximity detection. Direct modifica...

biorxiv.org

Cells are not just bags of molecules. Function depends on spatial interactions: RNAs and/or proteins come together with interaction partners to drive regulation and function. In our new preprint, we introduce ProPER, a novel method for in situ proximity detection. Preprint: tinyurl.com/muju86s6

Jorge Trojanowski@jorgetrojanowski.bsky.social · 3mo ago

1/ ProPER - Our novel ligation-free proximity detection method for efficient multiplexed imaging of molecular interactions in situ. Among other things we use it to image the life cycle of RNA molecules and resolve differential kinetics of gene expression steps. New preprint: doi.org/10.64898/202...

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling www.biorxiv.org/content/10.6...

Kristina@jekristina.bsky.social · 5mo ago

Ever felt constrained by the "4-color limit" in fluorescence imaging? We use DNA-barcoded labeling to build high-plex panels, enabling imaging of 15 targets across the full fluorescence spectrum. doi.org/10.64898/202... Grateful to @sinemsaka.bsky.social and all authors for making this possible.

I am delighted to co-organize the 2nd #ESSB meeting as an #EMBL Conference, with incredible support of @events.embl.org. Abstract submission deadline is July 15! #ESSB members submitting an abstract are eligible for one of 100 registration subsidy awards (up to 50%). #ESSB2025 #EMBLSpatialBiology

EMBL Events@events.embl.org · last yr.

‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉 https://s.embl.org/spb25-01-bl 📅 14–17 Oct 📍EMBL Heidelberg and Virtual ✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information

We had a lovely week in Heidelberg teaching ins and outs of #spatialbiology, and providing hands-on training for custom protocols like #immuno-saber, #ibex, #hybRISS. Massive thanks to my co-organizers, our dedicated trainers and excellent speakers, and #EMBO, #EMBL & sponsors. #EMBOSpatialOmics

Imaging-based spatial-omics

embl.org

EMBL Events@events.embl.org · last yr.

🥙 That's a wrap! #EMBOSpatioOmics is officially over. This course provided an introduction to the various methods of spatial-omics. We hope you were able to gain valuable knowledge for your research! 🙌 A big thank you to all of our participants, organisers, speakers, and trainers 👏

We are happy to participate in the ARISE program and have a range of collaborative opportunities for various backgrounds including biochemistry, imaging, omics or lab automation. Get in touch if interested!

EMBL@embl.org · last yr.

Interested in research infrastructures career? The #ARISE2 Fellowship Programme might be right for you. MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪 🗓️ Call opening: 30 June www.embl.org/training/ari...

We are repeating our EMBO Practical course for imaging-based spatial omics this June in Heidelberg. We will cover sample preparation, multiplexed IF (IBEX and Immuno-SABER), antibody-DNA conjugation, in situ sequencing, data analysis and visualization. Lots of fun and in-depth discussions!

EMBL Events@events.embl.org · last yr.

Would you like to get a comprehensive introduction to the various methods of spatial-omics and in particular those of multiplex immunofluorescence and spatial transcriptomics? Then apply for #EMBOSpatialOmics by 10 March here 👉 s.embl.org/iso25-01-bl #microscopy #imageanalysis #spatialbiology

The beautiful DNA-microart created by the wonderful Jennifer Heck and Kristina Jevdokimenko in our group to celebrate the festive season: Using Light-Seq, pixels of a DNA canvas was "painted" on a microscope by photocrosslinking DNA barcodes with 3 different fluorophores @embl.org's PhD course '24

The 1st European Society for Spatial Biology (#ESSB) meeting has been a blast! Great talks, exciting posters, new tech platforms and a budding vibrant community - made this a joy beyond our expectations. See you all again next year's edition at @embl.org Heidelberg on 14-17 Oct 2025!

Come be our colleague at @embl.org! New EMBL Group Leader applications are open until the end of the year: 1. www.embl.org/jobs/positio... 2. www.embl.org/jobs/positio... @futurepislack.bsky.social #genome #FuturePI

EMBL Jobs

We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

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