New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing? Check out this work led by postdoc Jingkun Zeng: www.biorxiv.org/content/10.6...

Exciting new paper by Harish Vasudevan et al! "IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors" www.jci.org/articles/vie... @neurosurgucsf.bsky.social @ucsfcancer.bsky.social @ucsfhealth.bsky.social

Journal of Clinical Investigation@jci.org · 7mo ago

Directly relevant to the care of patients with the most common malignant tumor of the peripheral nervous system👇 Zhu et al. reveal transcriptional, functional genetic & cellular mechanisms of IFN signaling that underlie radiotherapy response in people with MPNST: doi.org/10.1172/JCI1...

New @ucsfhealth.bsky.social research building coming out nice and shiny in the Inner Sunset winter-in-SF glow. Exciting things to come here.

Honored to be part of the Sontag Foundation family!

UCSF Radiation Oncology@ucsfradonc.bsky.social · 10mo ago

Congrats to @sjohnliu.bsky.social named 1 of 3 recipients of this yr’s Distinguished Scientist Award from The Sontag Foundation! It will support research using new functional genomic techniques to find better therapies for glioblastoma @neurosurgucsf.bsky.social @ucsfcancer.bsky.social

The lab was well represented at #SNO2025 in Honolulu spanning 4 presentations. Congratulations, team! @neurosurgucsf.bsky.social @ucsfradonc.bsky.social

November in SF

We are recruiting a postdoctoral fellow in our UCSF lab to work collaboratively on functional genomics methods for brain tumor biology and therapeutics development! opportunities.ucsf.edu/content/post...

Celebrating Chris’s admission to graduate school. The future is bright!

Our latest paper on CRISPR-enabled epigenetic editing in glioblastoma is out in @neuroonc.bsky.social! academic.oup.com/neuro-oncolo...

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy

AbstractBackground. Glioblastoma (GBM) carries a poor prognosis, and new therapeutic strategies are necessary to improve outcomes for patients with this di

academic.oup.com

Happy Holidays from our lab to yours!

Wonderful time at #SNO2024 catching up with friends, exchanging knowledge, seeing my mentor Dr. Mitch Berger receive the Lifetime Achievement Award, and a 10k along the Bayou in Houston. @neurosurgucsf.bsky.social