SMPS4

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Single Molecule Protein Sequencing 2025

We concluded #SMPS4 with a thought-provoking panel discussion on 'The Future of the Field.' A fitting end to an incredible conference, exploring the next frontiers in single-molecule protein sequencing!

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Martin Charron from the University of Ottawa delivered a talk on 'Predicting Nanopore Electrical Signatures using Accurate Access Resistance Models for Optimized Protein Analysis.' #SMPS4

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Justin Cronk from ETH Zürich presented on 'Adaptive Interfacial Nanopores with Glass Capillaries toward Protein Characterisation.' An innovative approach to advancing protein analysis! #SMPS4

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Deanpen Japrung from the National Science and Technology Development Agency delivered a talk on 'Advanced Nanopore Sensing and AI-Driven Classification of Human Serum Albumin Variants: Implications for Kidney Function and Diabetes Diagnostics. #SMPS4

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We kick off the final day of #SMPS4 with Casey Platnich from the University of Cambridge, presenting on 'Nanopore sensing enables detection of topologically barcoded RNA and their associated proteins.' An exciting start to wrap up this incredible conference!

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Xun Xu from MGI, one of our sponsors, wrapped up today’s sessions with a presentation on 'High-throughput Nanopore-based Peptide Sensing System.' We’re thankful for MGI's support! #SMPS4

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Jagannath Swaminathan from Erisyon, one of our sponsors, presented on 'Robust and scalable single-molecule protein sequencing with fluorosequencing.' We are grateful for Erisyon's support! #SMPS4

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Andrew Heron, CEO of Portal Biotech and one of our sponsors, presented on 'Single-molecule identification and comprehensive PTM profiling of full-length proteins with nanopores.' We’re grateful for Portal Biotech's support! #SMPS4

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Federico Thei, CEO and co-founder of Elements SRL, one of the proud sponsors of #SMPS4, shared his insights during a special session. We are grateful for Elements SRL’s support and Federico's engaging contribution to the conference!

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Pranjal Sur from the Indian Institute of Science presented on 'Orientation Dependence of Current Blockade in Single Amino Acid Translocation through a Graphene Nanopore.' #SMPS4

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Chen Kaikai from the University of Chinese Academy of Sciences delivered an enlightening talk on 'High-resolution glass nanopores for single-molecule detection.' #SMPS4

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Ralph Scheicher from Uppsala University delivered an insightful talk on 'Insights from computational modelling: modified hydrophobic nanopores and impact of neighboring amino acids.' #SMPS4

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Klara Hlouchova from Charles University gave an engaging presentation on 'Exploration of peptide sequence space: en route from prebiotic to biotic catalysis.' #SMPS4

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Bauke Albada from Wageningen University & Research presented on 'An Orthogonal Click Approach to Convert Biological Proteins into Peptide-DNA Conjugates for Nanopore Reading. #SMPS4

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Javier Kipen from KTH (Royal Institute of Technology) presented on 'Brownian motion data augmentation: a method to push neural network performance on nanopore sensors. #SMPS4

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Amr Makhamreh from Northeastern University took the stage to present on 'Enzyme-Free Translocations of Denatured Proteins with Sequence Block Permutations through CytK Nanopores Yield Reproducible Signal Patterns. #SMPS4

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Our next speaker, Joe Buonomo from the University of Texas at Arlington, presented on 'Scalable Native Peptide Sequencing Via Innovation in “Click” Chemistries and Large Language Models. #SMPS4

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Our second speaker of the day, Sang Wook Lee from Ewha Womans University, delivered a captivating talk on 'Nano- and Micro-Electromechanical Mass Sensor with Sub-Zeptogram Resolution: Towards Single Molecule Protein Sequencing. #SMPS4

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We started today with Aleksei Aksimentiev from the University of Illinois at Urbana-Champaign. He presented on 'Deciphering ionic current signatures of peptide transport through a biological nanopore #SMPS4

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The final presentation of the day was by Wei-Lun Hsu from The University of Tokyo, who discussed 'Peptide Sensing by Monolayer Molybdenum Disulfide Nanopores. #SMPS4

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Marija Drndic from the University of Pennsylvania followed with an intriguing talk on 'Investigation of folding dynamics of protein and peptide-oligonucleotide conjugates via solid-state nanopores. #SMPS4

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Big thanks to Kevin Freedman from the University of California Riverside for their engaging talk on 'Towards Deep-UV Raman Spectral Parsing of Amino Acid Side Chains inside a Plasmonic Nanopore. #SMPS4

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Next, Javier Alfaro from the University of Gdansk took the stage to discuss 'Protein sequencing in complex mixtures by mass-spectrometry: How far have we come towards sequencing the proteome? #SMPS4

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