Sonja Hofer

@sonjahofer.bsky.social

Neuroscientist studying neural circuits underlying perception and behaviour. Professor at the Sainsbury's Wellcome Centre, London

Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...

A subcortical switchboard for perseverative, exploratory and disengaged states - Nature

Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...

nature.com

So excited to see this out, heroic effort by the brilliant Sara Mederos, uncovering the detailed brain mechanisms of how animals learn to overcome their instinctive fear responses, from neural circuits & cell types down to synaptic plasticity mechanism! www.science.org/doi/10.1126/...

Overwriting an instinct: Visual cortex instructs learning to suppress fear responses

Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals can adapt their behavior and suppress instinctive reactions, but the neural pathways...

science.org