🧫✨ New paper in @wiley.com: Optical Manipulation of Whispering Gallery Mode Microlasers for Controlled Cellular Delivery We use laser tweezers to place microlasers onto single cells and watch their uptake in real time: doi.org/10.1002/adom... @thegatherlab.bsky.social @centrelightlife.bsky.social

2 postdoctoral researcher positions are available in the Structured Light Group in Exeter (UK). Project focussed on quantum & classical light control through dynamic complex scattering media (see concept picture). Details are below. Drop me an email if you'd like to know more! 🧪💡

DEFORM-Net out in npj Artificial Intelligence — an #open-source, unsupervised deep learning tool for full-field displacement estimation in microscopy videos with #ImageJ #FIJI plugin. Led by Philip Wijesinghe & Soloman Warsop — huge congratulations to the whole team! www.nature.com/articles/s44...

Estimating full-field displacement in biological images using deep learning - npj Artificial Intelligence

npj Artificial Intelligence - Estimating full-field displacement in biological images using deep learning

nature.com

Many thanks to all for this great collaboration pushing further the limits of microlasers - this time for DNA sensing. In particular to former #HCNB postdoc @sorayacaixeiro.bsky.social now at UBath and our friends from @kathlab.bsky.social in organic chemistry @chemunicologne.bsky.social.

Stephanie Kath-Schorr@kathlab.bsky.social · last yr.

🧬🔬New paper online: Nucleic acid sensing using DNA-functionalized whispering gallery mode microlasers! Great collaboration with @thegatherlab.bsky.social @sorayacaixeiro @schubertlab.bsky.social @chemunicologne.bsky.social 🧪 #DNASensing #microlasers pubs.acs.org/doi/full/10....

Ahead of International Women's Day 2025, staff and students have been celebrating the amazing women in our University community by contributing to our wall of appreciation in the library. See some of the plaques here ⤵️ @uniofbathnews.bsky.social

🧬🔬New paper online: Nucleic acid sensing using DNA-functionalized whispering gallery mode microlasers! Great collaboration with @thegatherlab.bsky.social @sorayacaixeiro @schubertlab.bsky.social @chemunicologne.bsky.social 🧪 #DNASensing #microlasers pubs.acs.org/doi/full/10....

DNA Sensing with Whispering Gallery Mode Microlasers

Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring, and molecular biology research by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers. By correlating spectral shifts in laser emission to changes in the refractive index, we demonstrate real-time detection of DNA hybridization and structural changes. The addition of gold nanoparticles to the DNA strands significantly enhances sensitivity, and exclusively labeling the sensing strand or a hairpin strand eliminates the need for secondary labeling of the target strand. We further show that ionic strength influences DNA compactness, and we introduce a hairpin-based system as a dual-purpose sensor and controlled release mechanism for drug delivery. This versatile WGM-based platform offers promise for sequence-specific nucleic acid sensing, multiplexed detection, and in vivo applications in diagnostics and cellular research.

pubs.acs.org