SPINA Team
@spinateam.bsky.social
Current news on the Structure Parameter Inference Approach, a #cybernetic method for the diagnostic evaluation of #endocrine #homeostasis #SPINAThyr #SPINA_Carb #SPINA_Thyr http://spina.sf.net http://spina.medizinische-kybernetik.de
Gestational #diabetes is a risk factor for diabetes mellitus in the newborn. A recent study found piglets born to hyperglycaemic mothers to have reduced #SPINA-GR, compensatorily increased #SPINA-GBeta and marginally reduced #SPINA-DI. doi.org/10.1007/s00125-026-06906-z
#SPINA-GT, while robust to central #thyroid dysfunction, slightly decreases due to therapy with #triiodothyroacetic_acid or #TRIAC in resistance to thyroid hormone beta. This may reflect #dynamical_compensation. doi.org/10.1016/j.eb... pubmed.ncbi.nlm.nih.gov/42874294/ www.livivo.de/doc/M42874294
Die #thyreotoxische_Krise ist ein endokriner Notfall, der unbehandelt fast immer tödlich ist. Wenn sie rechtzeitig erkannt und richtig behandelt wird, ist die Prognose aber gut. In einem Podcast diskutieren Dr. Kai Gruhn und ich Aspekte der Diagnostik & Therapie: open.spotify.com/episode/3bnY...
Thyreotoxische Krise: wichtige Differentialdiagnose der Sepsis - mit Prof. Johannes Dietrich
Klinisch Relevant Podcast · Episode
open.spotify.com
The R package for #SPINA has been upgraded to version 5.1. It includes both #SPINA_Thyr and #SPINA_Carb. More information is available at cran.r-project.org/web/packages... Packages for macOS and Linux are ready. For Windows, they will be available in a few days. @r-foundation.bsky.social #RStats
Given the possibility of #Syndrome_T, not all patients who undergo #hemithyroidectomy will benefit. Two new risk scores identify predictors for #hypothyroidism, warranting therapy with #levothyroxine. #thyroid #QoL doi.org/10.3390/diag... 🧪 🩺 #MedSky @medsky.social Endocrinology #Endosky
After #hemithyroidectomy, some patients will develop #hypothyroidism, whilst in others the #thyroid continues to function. The best parameter to predict postoperative hypothyroidism is #SPINA-GT. #SPINA_Thyr doi.org/10.3390/diag...
#Thyroid dysfunction may cause sudden death. However, thyroid hormones respond to #stress as well. A recent autopsy study found #SPINA-GD or Jostel's TSH index increased in all cases, highlighting the importance of type 2 #allostatic_load. pubmed.ncbi.nlm.nih.gov/41997212/ doi.org/10.1055/a-28...
#Thyroid #hormones play a critical role in the central nervous system. Recent research shows that #SPINA-GT is associated with progression-related motor heterogeneity in spinocerebellar ataxia type 3. pubmed.ncbi.nlm.nih.gov/42251968/ doi.org/10.1016/j.nb... www.livivo.de/doc/M42251968
Our book on #Hypothyroidism is now available in 5 formats: Printed hardcover, printed softcover (both in full colour), MyCopy softcover (price reduced, monochrome, for members of universities) and 2 eBooks (PDF and EPUB), rendering it accessible to more readers. doi.org/10.1007/978-...
#MCT8 deficiency or #Allan-Herndon-Dudley syndrome is a rare disorder of #thyroid hormone transport, leading to severe neurodevelopmental delay. See our newest paper for monitoring recommendations. pubmed.ncbi.nlm.nih.gov/41926547/ doi.org/10.1159/0005... www.livivo.de/doc/M41926547
In women with latent (i. e., euthyroid) autoimmune #thyroiditis, both #SPINA-GT and #SPINA-GD rise in #pregnancy, provided the supply of #selenium and vitamin D is sufficient. This observation may reflect physiological type 2 #allostatic reactions or reduced autoimmunity. doi.org/10.3390/nu18...
🧪 🩺 #MedSky @medsky.social #Endocrinology #Endosky
SimulAdrenTeam@simuladrenteam.bsky.social · 6mo ago#SimulAdren, the open dynamic simulator for the #HPA-axis, i. e. the #hypothalamus-pituitary-adrenal feedback control, has been released in version 2.0.1. This is a recommended update that fixes several bugs. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...
The Mediterranean diet reduces the workload of pancreatic #beta-cells, as measured by their secretory capacity (#SPINA-GBeta). 🩺 #MedSky @medsky.social #Endocrinology #Endosky pubmed.ncbi.nlm.nih.gov/42124052/ doi.org/10.3390/nu18... www.livivo.de/doc/M42124052
Wiley sent us a note that our paper defining the static disposition index #SPINA-DI is among the top-viewed articles of the Journal of Diabetes. pubmed.ncbi.nlm.nih.gov/38169110/ doi.org/10.1111/1753... www.livivo.de/doc/M38169110
![Abstract
Aims: The widely used dynamic disposition index, derived from oral glucose tolerance testing, is an integrative measure of the homeostatic performance of the insulin-glucose feedback control. Its collection is, however, time consuming and expensive. We, therefore, pursued the question if such a measure can be calculated at baseline/fasting conditions using plasma concentrations of insulin and glucose.
Methods: A new fasting-based disposition index (structure parameter inference approach-disposition index [SPINA-DI]) was calculated as the product of the reconstructed insulin receptor gain (SPINA-GR) times the secretory capacity of pancreatic beta cells (SPINA-GBeta). The novel index was evaluated in computer simulations and in three independent, multiethnic cohorts. The objectives were distribution in various populations, diagnostic performance, reliability and correlation to established physiological biomarkers of carbohydrate metabolism.
Results: Mathematical and in-silico analysis demonstrated SPINA-DI to mirror the hyperbolic relationship between insulin sensitivity and beta-cell function and to represent an optimum of the homeostatic control. It significantly correlates to the oral glucose tolerance test based disposition index and other important physiological parameters. Furthermore, it revealed higher discriminatory power for the diagnosis of (pre)diabetes and superior retest reliability than other static and dynamic function tests of glucose homeostasis.
Conclusions: SPINA-DI is a novel simple reliable and inexpensive marker of insulin-glucose homeostasis suitable for screening purposes and a wider clinical application.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:yxkip4xxf4mlialvuuoisc2w/bafkreidjchyquyfdzhiisypyqhskslenupf3d7wgc7ffwaryfvjeibdysy)
Another study highlights advantages of SPINA-GBeta over the #HOMA method, here with correlation to the adherence of #mediterranean diet. #SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI doi.org/10.3390/nu18...
#SPINA-GT correlates to the grading of colour #Doppler #ultrasound investigations in #hyperthyroidism and #thyrotoxicosis. pubmed.ncbi.nlm.nih.gov/35942151/ www.livivo.de/doc/M35942151 doi.org/10.1155/2022...
In an adjusted model, #SPINA-GD correlates significantly with type 2 allostatic load. It parallels the association to central markers of thyroid homeostasis, underscoring the TSH-T3 feedforward control. #thyroid #allostasis pubmed.ncbi.nlm.nih.gov/41941533/ doi.org/10.1080/1025...
#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...
Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy. pubmed.ncbi.nlm.nih.gov/41852474/ doi.org/10.3389/fend...
Diagnosis of #diabetes mellitus and #prediabetes: A simple calculation may be better than a complex test. 🧪 🩺 #MedSky @medsky.social #Endosky #Endocrinology medicalxpress.com/news/2024-01...
New calculation offers simple and reliable early prediction of diabetes
Diabetes often remains undetected until it has already damaged organs or nerves. This is partly due to the fact that diagnosis at an early stage is time-consuming and difficult.
medicalxpress.com
#Takotsubo syndrome (TTS) is a poorly understood life-threatening #cardiomyopathy. With machine learning, we found 3 signatures of #thyroid #homeostasis heralding the prognosis of patients affected by TTS. pubmed.ncbi.nlm.nih.gov/38502972/ doi.org/10.1016/j.eb... www.livivo.de/doc/M38502972
#Takotsubo syndrome is a dangerous stress-related #heart disease. Since #T3 upregulates β-receptors, we assumed a link to #thyroid homeostasis. With machine learning, we identified interesting allostatic patterns. www.livivo.de/doc/M33179374 pubmed.ncbi.nlm.nih.gov/33179374/ doi.org/10.1111/joim...
Previsione precoce semplice e affidabile del diabete blogpinali.wordpress.com/2024/01/23/p...
Previsione precoce semplice e affidabile del diabete.
Il diabete spesso rimane inosservato finché non ha già danneggiato organi o nervi. Ciò è in parte dovuto al fatto che la diagnosi in fase precoce è difficile e dispendiosa in termini di tempo. Un t…
blogpinali.wordpress.com
Mathematical modelling of #insulin-#glucose #homeostasis delivers new and improved methods for metabolic endotyping. #prediabetes #diabetes #metabolic_syndrome #betacell pubmed.ncbi.nlm.nih.gov/36271244/ doi.org/10.1038/s415...
: glucose concentration; S(t): insulin secretion rate; [I](t): insulin concentration; M(t): proximal insulin signalling; N(t) distal insulin signalling; P(t): constitutive glucose production rate; Q(t): regulated glucose production rate; W(t): intestinal glucose absorption rate; R(t): glucose arrival rate. G1 and G3 represent gains of ASIA elements. Units of measurement are displayed in the small, rounded boxes with red margins.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:xaqslchhhuackby4i46m33e2/bafkreihh46ymprtcws7a6xj55tmyccuu4sfa7rpg7ltqwflbfxxnickqwu)
Gestational #diabetes mellitus (GDM) is linked to significant adverse outcomes for both mothers and their offspring. Since #SPINA-GBeta outperforms #HOMA-Beta, its use is advised as a preferred calculated #biomarker for the evolution and pathophysiology of #GDM. pubmed.ncbi.nlm.nih.gov/40943638/
Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics
Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study. pubmed.ncbi.nlm.nih.gov/40579157/ doi.org/10.1210/clin...
