🧵 #Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org A great collab. w/ @weiss-lab.bsky.social #TeamTomo @hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social link.springer.com/article/10.1...

The calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO Journal

Multicellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...

link.springer.com

Bacterial Multicellularity Tips: Let's Learn Together and Spark Our Curiosity!

Cannibalism shapes biofilm structure and composition in Bacillus subtilis mBio by Lena Friebel from Thosten Mascher group within @spp2389.bsky.social DFG program journals.asm.org/doi/10.1128/... Superb summary of colony phenotypes in figure 1

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis #MolMicrobiol from Thorsten Mascher @spp2389.bsky.social, Rut Carballido-López and colleagues onlinelibrary.wiley.com/doi/10.1111/...

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall-targeting antimicrobials, combining RNAseq and high-resolution tilin...

onlinelibrary.wiley.com

Impressions of Bakteriopolis in Cosmo! Come try out a new memory game, check out the microbe of the year Penicillium chrysogenum (@vaam-microbes.bsky.social), or travel through an interactive timeline on the origin of life 🦠 Don’t miss upcoming workshops on fungal mycelium on 30.04. and 05.05. 🍄

Our traveling exhibition Bakteriopolis is in the Cosmo Wissenschaftsforum this month! 🦠🔬 Come talk to scientists, learn about fermented foods, see the microbe of the year Penicillium up close and much more! Every Tuesday - Thursday 13:00 - 18:00 Schloßstraße 2 01067 Dresden

A family of endonucleases blocks nanotube-mediated plasmid exchange YokF encoded within prophage @natmicrobiol.nature.com from Sigal Ben-Yehuda, Ilan Rosenshine with Boris Maček within ERCSyG and @spp2389.bsky.social www.nature.com/articles/s41...

A family of endonucleases blocks nanotube-mediated plasmid exchange - Nature Microbiology

The YokF endonuclease provides a donor-controlled mechanism to limit plasmid transfer to recipient bacteria via nanotubes in Bacillus subtilis, with YokF functional homologues found across Gram-positi...

nature.com

What started out as a student project has grown over the last 2 years into a full-fledged review! So many thanks to @escolizzi.bsky.social for leading this multicellular effort and sharing your evolutionary wisdom with us 🫶🏻🦠

Enrico Sandro Colizzi@escolizzi.bsky.social · 5mo ago

How common is multicellularity in bacteria? And archaea? And how does it evolve? We wrote a short review "On the architecture and evolution of prokaryotic multicellularity". Preprint link: bit.ly/4ta06Gq Sharing and comments are much appreciated. 1/4

A bacterial extracellular matrix protein forms a supramolecular metallogel [=Bacillus subtilis TasA and Zn] bioRxiv from Liraz Chai with @vasilyzaburdaev.bsky.social within @spp2389.bsky.social www.biorxiv.org/content/10.6...

Interested in the regulation and evolution of multicellularity in Strepromyces? Natalia Tschowri (@unihannover.bsky.social) and Daniel Rozen (@unileiden.bsky.social) are looking for a PhD student as part of #SPP2389 ! #PhDposition

Ákos T Kovács@evolvedbiofilm.bsky.social · 6mo ago

PhD position with Natalia Tschowri (@unihannover.bsky.social) and Daniel Rozen (@unileiden.bsky.social @leidenscience.bsky.social) within @spp2389.bsky.social program Regulation and Evolution of Bacterial Multicellularity Application deadline until 15 March 2026 #PhDposition

And we’re back! The second funding period of #SPP2389 started this week with our kickoff meeting in Grimma Stay tuned in the next few weeks/months to get to know both the old and new members working on projects centered around the fascinating world of bacterial multicellularity! 🦠

Our latest paper on Guanidine metabolism in #Cyanobacteria is out @pnas.org (it's useful as N nutrient but toxic at the same time) A great collaboration w Klähn lab w small part from us on toxicity😅 @hhu.de @spp2389.bsky.social @sfb1381.bsky.social @mibinet.bsky.social www.pnas.org/doi/10.1073/...

Deciphering guanidine assimilation and riboswitch-based gene regulation in cyanobacteria for synthetic biology applications | PNAS

Guanidine is well known as a denaturing agent. However, recent studies have demonstrated both the widespread synthesis of guanidine, e.g., in plant...

pnas.org

Last chance to visit Bakteriopolis at the @tudresden.bsky.social Excellence Days event!

TU Dresden@tudresden.bsky.social · 9mo ago

"Excellence Days" auf der Mommsenstraße: Nach dem Auftakt heute habt ihr morgen nochmal die Möglichkeit, zwischen 11 und 15 Uhr die exzellente Forschung der TUD zu erleben. ✨ Vor der Alten Mensa präsentieren sich die Exzellenzcluster sowie @joddid-forschung.bsky.social, das COSMO & viele mehr.

Surface matters! Chitin alters both intraspecies interactions and biofilm architecture in Vibrio cholerae in marine snow Preprint on @biorxiv-microbiol.bsky.social ⬇️

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 10mo ago

Vibrio cholerae interaction with predatory bacteria on chitin suggests an alternative mode of biofilm formation in marine snow conditions https://www.biorxiv.org/content/10.1101/2025.10.31.685833v1

Cellulose is a critical component in the cell wall of Streptomyces, and accessory proteins involved in its biosynthesis support both its unique cell envelope and multicellular filamentous growth From Daniel Claessens’ lab in @cp-trendsmicrobiol.bsky.social #microsky #streptomyces #multicellularity

Trends in Microbiology@cp-trendsmicrobiol.bsky.social · 10mo ago

Cellulose biosynthesis and function in Streptomyces

Bakteriopolis is in Halle at the #SilbersalzFestival this week! Even Come try water kefir, make your own bacterium, and learn about the hidden world of multicellular microbes! #SPP2389 #microsky #wisskomm Danke an Mainzelmännchen Det für den Besuch! @zdfde.bsky.social

@kostchristian.bsky.social has an open PhD position as a part of #SPP2389 ! #microsky #mevosky

Christian Kost@kostchristian.bsky.social · 10mo ago

#microsky #mevosky @spp2389.bsky.social A PhD position is available in my lab to work on: Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria. Please RT Deadline: 12.11.25 More infos 👇 shorturl.at/rAKAT

Evolution of One Species Increases Resistance to Invasion in a Simple Synthetic Community Microbial Ecology link.springer.com/article/10.1...

Evolution of One Species Increases Resistance to Invasion in a Simple Synthetic Community - Microbial Ecology

The species that make up a microbial community determine its potential function. A major goal of microbial ecology is to make assemblages of microbes — synthetic communities — with targeted applicatio...

link.springer.com

Interested in working on microbial interactions and cooperative cross-feeding? Join @kostchristian.bsky.social as a part of #SPP2389 !

Christian Kost@kostchristian.bsky.social · 10mo ago

#microsky #mevosky @spp2389.bsky.social A PhD position is available in my lab to work on: Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria. Please RT Deadline: 12.11.25 More infos 👇 shorturl.at/rAKAT

From polymicrobial water kefir grains to PCD in biofilms, microorganisms are magnificently multicellular! Thanks to @embo.org @ibe-barcelona.bsky.social for having Lena Friebel and Thorsten Mascher @tudresden.bsky.social as well as @escolizzi.bsky.social at the #Multicellverse workshop

You can’t talk about microbial multicellularity without mentioning Streptomyces - check out our collaborator Daniel Rozen’s experimental evolution of these filamentous bacteria! Thanks @martaalvarez.bsky.social for snapping a pic! @embo.org #Multicellverse

Marta Álvarez-Presas@martaalvarez.bsky.social · 11mo ago

Daniel Rozen is now talking about experimental evolution in Streptomyces. #Multicellverse

Our head of #SPP2389 Thorsten Mascher also put the spotlight on the multicellular microbial communities of water kefir - thanks again @evolvedbiofilm.bsky.social ! @embo.org #Multicellverse

Ákos T Kovács@evolvedbiofilm.bsky.social · 11mo ago

Thorsten Mascher, speaker of @spp2389.bsky.social at #Multicellverse 👇🏼

Lena brought her research on cannibalism in Bacillus biofilms to the @embo.org multicellularity workshop! Thanks @evolvedbiofilm.bsky.social for the picture! #Multicellverse

Ákos T Kovács@evolvedbiofilm.bsky.social · 11mo ago

@spp2389.bsky.social at #Multicellverse 👇🏼

All cells – from mammalian cells to microbes – can follow different biological paths. Whether they grow and divide, specialise, age or die depends on the pathway they take. New findings by researchers at ETH Zurich could help influence a cell’s decisions to target diseases such as cancer.

Protein condensates determine a cell’s fate

Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.

ethz.ch

A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social www.cell.com/iscience/ful... #cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano @hhu.de @mibinet.bsky.social

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade

Biological sciences; Biochemistry; Microbiology; PII-like protein SbtB; c-di-AMP signaling; Cyanobacteria; Carbon/Nitrogen metabolism; Redox imbalance; Photosynthesis; Reactive oxygen species (ROS); C...

cell.com

PhD position on Regulation and Evolution of Bacterial Multicellularity ( #Streptomyces ) within @spp2389.bsky.social supervised by Natalia Tschowri (Hannover 🇩🇪) and Danny Rozen (Leiden 🇳🇱) with research at both locations deadline: October 31, 2025 www.uni-hannover.de/en/jobs/id/802

Streptomyces and other filamentous actinomycetes are treasure troves of a vast collection of antibiotic compounds - an evolutionary feature linked to their unique multicellular lifestyle

Matt Hutchings@matthutchings.bsky.social · 11mo ago

The million dollar question…new review from Matt Tracker and colleagues www.annualreviews.org/content/jour...

Curious about kin recognition systems? Take notes from Proteus and Myxococcus! @ucberkeleyofficial.bsky.social

Ákos T Kovács@evolvedbiofilm.bsky.social · 12mo ago

Kin Recognition Systems and Their Role in Multicellular Behaviors #AnnuRevMicrobiol by Karin Yaniv and Karine Gibbs @ucberkeleyofficial.bsky.social four bacterial and eukaryotic microorganisms with collective migration where recognition is known or implied www.annualreviews.org/content/jour...

Congratulations to our Matthias for winning the @femsmicro.org international microorganism day microbe art contest for best photo and best overall! 🎉🦠 Biofilms truly are beautiful works of multicellular microbial architecture 🏛️ www.internationalmicroorganismday.org/microbeart

International Microorganism Day - Microbe Art Contest Winners

internationalmicroorganismday.org

A bit late to the party, but happy belated international microorganism day!

FEMS@femsmicro.org · 11mo ago

Happy International Microorganism Day! 🎉 Today, we are celebrating the tiny powerhouses that have a massive impact on our world. From the bacteria in our gut to the fungi that give us antibiotics, these incredible organisms are essential to life. Let's make some noise for the microscopic!