Leif Østergaard
@stergaard-leif.bsky.social
Neuroscientist interested in brain energy metabolism in brain health and disease. Professor and director, CFIN, Dept. Clinical Medicine, Aarhus University. Consultant and Head, Neuroradiology Research, Aarhus University Hospital. www.cfin.au.dk
Nicolay Kutuzov is the final Hot Topic Poster presenter. He talks about super-localization two-photon microscopy for tracking blood vessel walls. Cool images🤩!
Line Mathilde Brostrup Hansen talks about effects of age and sex on stroke outcomes in a mouse model (slight change from poster). After ischemia-reperfusion, older mice did worse - and sex needs to be taken into account. #CTH2024
Hot Topic Poster presentation by Jacqueline Condrau on endothelial injury: microglia enwrap the injured capillary but this is not necessary for capillary repair. Neither were pericytes and astrocytes🤯. Answer? Neighbouring endothelial cell extensions.
Great talk by Yamei Tang on radiation-induced brain injury. Pericytes are extremely sensitive to radiation: Reduced pericyte coverage, signs of mural cell damage. Thalidomide treatment salvaged pericytes, capillaries, BBB integrity, neuronal function in mice🤩 Enormous translational potential!
Eugenio Gutierrez-Jimenez presented a comprehensive study of carbonanhydrase inhibitor effects in the presymotomatic phase of Alzheimers Disease in a mouse model: reduces amyloid load, proteomic changes and hints of microvascular, oxygenation changes 🤩. #CTH2024. Out of battery😬) See
Changing gears to look at human microvascular hemodynamics. Simon Fristed Eskildsen talks about microvascular flow disturbances in Alzheimers Disease and mild cognitive impairment (MCI). #CTH2024
Tour de force through methods, models and concepts for understanding the BOLD signal by Michele Desjardins - amazing, multimodal and multidisciplinary work from Desjardin lab🤩. #CTH2024
Ravi Rungta presents cool studies of layer-specific flow responses in whisker barrel cortex 🤩. Why does vasodilation show little selectivity? Capillary dilation is tuned to downstream activity in layer 4.
Mindblowing talk by Cristine Alberini: IGF-2 from pericytes is required for term memory formation. She points out that IGF-2 signaling is implicated in multiple brain disorders. Multiple opportunities for collaboration: neural plasticity - microvascular plasticity! #CTH2024
Krzysztof Kucharz (Lauritzen Lab) is the third #CTH2024 Hot Topic presenter - about microvascular changes in an animal model of Huntingtons Disease - a devastating neurodegenerative disorder
Anna Devor conceived and champions the #BrainMicrocirculation workshop’s Hot Topic Poster presentation sessions - giving early career researchers an opportunity to present their work and discuss their finding
Marine Tournissac (Charpak Lab) is the second Hot Topic Poster presenter. She investigated the difference between CO2- and brain activation- related hyperemia
Hot Topic Poster presentation #CTH2024 - Kevin Elk (Mishra lab) is the first of 6 posters selected for an oral presentation - at very short notice😬! Great talk on pericyte function!
Mickael Tanter: Clinical application-impressive 🤩! Micro bubbles are 3 micrometers.
Mickael Tanter presents amazing ultrasound images of the brain circulation - and brain activity 🤩
Franca Schmid presents amazing model findings that increase our understanding of the importance of collaterals and of what happens after pericyte loss and capillary occlusions. Take home from modeling talks: we need more detailed images of microvascular trees - especially in deep cortex layers.
Sylvie Lorthois gives impressive talk on modeling the microcirculation - long transit times and poor oxygenation/amyloid removal may be more common - and harder to measure - than we believe #CTH2024
Timothy Secomb, a giant within our understanding of blood flow and oxygen transport in microvascular networks, kicks off the modeling session🤩 #CTH2024
Vladimir Matchkov talks about capillary hemodynamics and neuro vascular coupling after ischemia-reperfusion.
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
Fabrice Fabertrand presents the elegant capillary-parenchymal preparation and novel studies of the mechanisms underlying pericyte responses to intra-luminal pressure #CTH2024
Tom Longden talks about plasticity in vascular signaling that accompanies brain plasticity. Cool pericyte activation method👌. Just out in PNAS - and #CTH2024🤩
Sava Sakadzic, Pioneer in 2-photon microscopy based brain oxygenation measurement methods introduces Felix Beinlich, who presents a bioluminescent oxygen sensor based method recently published in Science by the Nedergaard group. #CTH2024
