Steven Shaw

@steven-shaw.bsky.social

Postdoctoral Researcher at the University of Bristol examining Anti-phage systems in the Szczelkun Lab| Biochemical, Biophysical and Nanopore

Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out: www.nature.com/articles/s41... Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

Stephan Gruber@gruberlab.bsky.social · last yr.

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).