We wanted to put over a decade of advances on the immunology surrounding fetal Zika infection in context in our review "Immune mechanisms of congenital Zika syndrome" @sciimmunology.bsky.social. So happy to see it's #openaccess! www.science.org/doi/10.1126/...

Immune mechanisms of congenital Zika syndrome

This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

science.org

Excited to be at the #HCVFlavi2025 meeting in Singapore! Great mix of cutting edge #HCV and #Flavivirus research. Thanks to @stjohnlab.bsky.social Heidi Drummer and Rowena Bull labs for organizing!

A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. Read more in #ScienceTranslationalMedicine: https://scim.ag/45ORL27

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

scim.ag

Dengue is rising. In Nepal, studying >500 #dengue patients, we found that waning immunity to Japanese encephalitis virus #JEV was associated with worsened dengue severity, which has implications for #vaccine campaign planning. First au🙌: @sidharth-malhotra.bsky.social www.science.org/doi/10.1126/...

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

science.org

Excited to share our new #OpenAccess review: "Maternal IgE Influence on Fetal and Infant Health" led by Jozef. We discuss how maternal #IgE shapes fetal immunity and the shift to intrinsic early-life IgE production, with implications for #allergy onset. 👉 doi.org/10.1111/imr....

Little break from talks to visit Knossos Palace… finally spending time with @zhijuanjexpmed.bsky.social not on zoom!

Registration now open for HCV-Flavi 2025!

Save the date for #HCVFlavi2025, a joint Asia-Pacific meeting to be held October 13-16, 2025 in Singapore at Duke-NUS Medical School! More info to come!

Microglia protect the fetal brain from Zika virus, while primitive macrophages and monocytes drive infection and inflammation, highlighting diverse immune roles. Plus other great insights. Great work from @stjohnlab.bsky.social www.cell.com/cell/abstrac...

Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection

Fetal microglia are protective against Zika virus, but primitive macrophages and monocytes promote neuroinflammation and are disease promoting. Different fetal immune and neuronal cell types are targeted by different Zika lineages.

cell.com

Did you know that the fetal immune system can protect from infection before birth? Check out our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection. authors.elsevier.com/a/1k4rcL7PXq...