Sträßer lab

@straesserlab.bsky.social

Passionate about uncovering how mRNPs form in the nucleus and how this intertwines with other aspects of gene expression. Based at Justus Liebig University Giessen, Germany. https://www.uni-giessen.de/de/fbz/fb08/Inst/biochem/straesser/

If after reading the article you are still hungry for more about alternative TREX-2 complexes, also check out the recent preprints from the labs of Torben Heick Jensen @heick.bsky.social and Mary Dasso 😉 www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.6...

biorxiv.org

RTG 2355@rtg2355.bsky.social · 4mo ago

Happy to share the Preview by RTG PIs Cornelia Kilchert & Katja Sträßer on the recent paper @cp-molcell.bsky.social by Tian et al on LENG8's role in nuclear RNA quality control. Here's 50 days' free access - so check it out before June 05, 2026! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Very happy to share the paper on nuclear mRNA export by Nataliia Stefanyshena now out in #NAR! Nataliia uncovered that, counterintuitively, an excess of the conserved mRNA exporter Mex67 in yeast messenger ribonucleoprotein particles (mRNPs) impairs mRNA export. academic.oup.com/nar/article/...

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export

Abstract. In eukaryotes, nuclear messenger RNA (mRNA) export is a crucial step in gene expression, mediated by the conserved mRNA exporter Mex67-Mtr2 in Sa

academic.oup.com

Happy to share the work by Fabienne Becker et al in #NAR, showing how yeast Tho1-CTD stimulates helicase activity of Sub2, homologue of human DDX39B/UAP56, by promoting Sub2 oligomerization on RNA. The scaffolding mechanism is shared across species: academic.oup.com/nar/article/...

Tho1 and MOS11 promote nucleic acid double-strand unwinding by facilitating DEAD-box helicase oligomerization

Abstract. DEAD-box helicases are essential for gene expression and RNA metabolism. However, the mechanisms regulating their activity remain largely elusive

academic.oup.com

Proud to bring together so many excellent invited speakers for our RTG 2355 International Conference next September, and looking forward to welcoming you @jlugiessen.bsky.social! 👉 tinyurl.com/rtg2355conf

RTG 2355@rtg2355.bsky.social · 8mo ago

Happy to announce our RTG 2355 International Conference “Regulatory landscapes of RNA: From code to control”, Sept 14-16, 2026 in Giessen, Germany. Topics cover #RNA as messenger, recruiting platform, sponge, regulator & sensor. 👉tinyurl.com/rtg2355conf Save the date – registration opens May 1!

And here goes another one - @rtg2355.bsky.social-member Fabienne Becker from the Friedhoff lab presented her research at the 2025 Helicase Conference in Lisbon today: "The Conserved C-terminal Domain of Tho1 Stimulates the DEAD-box Helicase Sub2" - more coming soon #proudCoordinator 😉

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