🎉 Our preprint “Dynamic Behavior ... of the Polymyxin Resistance Determinant MCR-1 ... in the Membrane Environment” in colab with @adrianmulholla1.bsky.social @marcvanderkamp.bsky.social is now published in JCIM. 📖 Read it here: pubs.acs.org/doi/10.1021/...

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment

The Mobile Colistin Resistance (MCR) phosphoethanolamine (PEtN) transferase is a plasmid-borne enzyme responsible for colistin antibiotic resistance in Escherichia coli, the most important antimicrobi...

pubs.acs.org

🚨 Check out the updated version of our latest preprint with @adrianmulholla1.bsky.social, @marcvanderkamp.bsky.social, and many others! 📄 Read it here 👉https://chemrxiv.org/engage/chemrxiv/article-details/685d6114c1cb1ecda080add6

First preprint post here 🧪 🧬, on the molecular mechanism of proton transport and coenzyme-Q reactivity catalyzed by respiratory complex III. Check it out if you are into #bioenergetics, #enzymes or #compchem www.biorxiv.org/content/10.1...

Redox-Activated Proton Transfer through a Redundant Network in the Qo Site of Cytochrome bc1

Proton translocation catalyzed by cytochrome bc 1 (respiratory complex III) during coenzyme-Q redox cycling is a critical bioenergetic process, yet its detailed molecular mechanism remains incompletel...

biorxiv.org

Solvent channels and proton transfer pathways in peroxidase catalysis Authors: Reynier Suardiaz, Hanna Kwon, Marc van der Kamp, Lola González-Sánchez, Peter Moody, Emma Raven, Adrian Mulholland DOI: 10.26434/chemrxiv-2024-rjrnd