Surrey Lab

@surreylab.bsky.social

Thomas Surrey's lab @crg.eu MICROTUBULES | Molecular Biochemistry | In vitro Reconstitutions 🦋 posts by lab members

And Zoë from our lab defended her PhD! 🎉 She’s been uncovering microtubule organization and mitotic spindle assembly using a little pet she created: the spider kinesin 🕷️ What, you’ve never heard of it? Stay tuned for what’s coming next! Congratulations Zoë!!! 👏🎓

Bild

⚡Ready to grow and be inspired as a scientist? We’re looking for a *PhD student* to join our lab at @crg.eu in Barcelona and explore how cells self-organize, uncovering life’s inner design💡 We offer strong mentoring, cutting-edge science, and a vibrant international team🌍 Check the link below!

Bild

🚨New paper out @pnas.org! Do you want to know how do mitotic motors organize the spindle? Wei Xiang's simulations show that just a plus & a minus motor are enough to drive bipolar spindle assembly. Could this explain why kinesin-5 & dynein evolved their unique properties? 🤔 doi.org/10.1073/pnas...

Molecular design principles for bipolar spindle organization by two opposing motors | PNAS

During cell division in animal cells, a bipolar spindle assembles to segregate the chromosomes. Various motor proteins with different properties ar...

pnas.org

We're on a roll!🚀 Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability. Congrats to Juan and everybody involved! 🎉

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap

Nature Communications - Estévez Gallego et al. present a study demonstrating that mosaic microtubules consisting of a mix of GTP hydrolysis-deficient tubulin mutants are faithful microtubule...

rdcu.be

Also, huge congrats to Sabina @bilirubina.bsky.social for not only publishing her work in JCB but also successfully defending her PhD thesis last Friday! 🎉 We're so proud of all you've accomplished over the past few years and excited to see what amazing things you will do next, Dr. Sabina! 🥳

Sabina Colombo@bilirubina.bsky.social · 2y ago

Se acabó! I finally got a #PhD 🎓🥂 4 years of tears & anxiety mixed with euphoria, the most genuine laughs & precious friendships. Fabulously chaotic. Thanks to all those big little #proteins, inside my body and inside the #microscopy chambers 🧪🔬✨ @crg.eu @upf.edu @prbb.org @surreylab.bsky.social

Fresh off the press! 🔬 Our team's new publication in the JCB sheds light on the intricate dance of spindle proteins and microtubules! 🕺💃Sabina (@bilirubina.bsky.social) demonstrates that NuMA acts as a mitotic dynein adaptor, binding and capping minus ends to focus them at mitotic spindle poles!

NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends | Journal of Cell Biology | Rockefeller University Press

Using microscopy-based in vitro reconstitutions, Colombo et al. show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, expl

buff.ly

Sabina Colombo@bilirubina.bsky.social · 2y ago

So thrilled to share my first paper as a first author. In these in vitro reconstitutions we observe how purified #spindle #proteins interact with #microtubules using #TIRF #microscopy 🔬👩🏻‍🔬 Grateful to those magic brains of the @surreylab.bsky.social for all the support along the way! 🫂