Adjuvant Chemotherapy After Resection of Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX

This cohort study investigates the association of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative FOLFIRINOX in full or modified dosing with overall survival,...

jamanetwork.com

The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography–derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma

The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomograp...

surgjournal.com

Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma

The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.

surgjournal.com

Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate? - Annals of Surgical Oncology

Introduction Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) candidates often have extraperitoneal abdominal disease. Current expert peritoneal surface malignancy (PSM) gui...

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Diagnostic Certainty in Characterizing Liver Lesions in Rectal Cancer: Abbreviated Liver MRI versus CT - Annals of Surgical Oncology

Background Early diagnosis of metastases is crucial but routine staging with contrast-enhanced multidetector computed tomography (ceMDCT) is suboptimal. A total of 20% will have indeterminate or too s...

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Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations - Annals of Surgical Oncology

Background Tumor microvasculature is an important component of the tumor microenvironment (TME), and it has been reported that tumor microvasculature induces TME to become immunosuppressive via vascul...

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Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network - Annals of Surgica...

Background Rectal tumors display varying degrees of response to total neoadjuvant therapy (TNT). We evaluated the performance of a convolutional neural network (CNN) in interpreting endoscopic images ...

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Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure - Annals of Surgical Oncology

Background Pancreaticoduodenectomy (PD) is a complex procedure involving the dissection of the superior mesenteric artery and vein. However, a safe and standardized technique for dissecting the jejuna...

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Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial

Slow intravenous (iv) hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the...

acsjournals.onlinelibrary.wiley.com

Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anae...

This is an international survey and case-vignette study including 1283 participants from 55 countries. Interrater variability regarding the ASA classificat

academic.oup.com

Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical...

This RCT investigated whether parenchymal pre-compression was effective in reducing pancreatic fistula in distal pancreatectomy. The proportion of patients

academic.oup.com

Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers - Annals of Surgical Onc...

Background Select patients with peritoneal metastases are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We assayed for intra- and interpatient drug resp...

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Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial - Annals of Surgical Oncolo...

Background Frailty, a multidimensional state leading to reduced physiologic reserve, is associated with worse postoperative outcomes. Despite the availability of various frailty tools, surgeons often ...

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Time to Surgery Does Not Affect the Survival Outcome in Patients with Perihilar Cholangiocarcinoma - Annals of Surgical Oncology

Background The impact of time to surgery (TTS) on survival in patients with perihilar cholangiocarcinoma (PHC) is uncertain. Methods Data from PHC patients scheduled for surgery between 2011 and 2020 ...

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Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

A systematic analysis of clinical trial data uncovers ancestral differences in clinical outcomes, providing insights to advance more precise treatments that are tailored to diverse populations.

aacrjournals.org

Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer - Nature Cancer

Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the conte...

nature.com

Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches

Tumor-intrinsic subtypes of pancreatic cancer are characterized by distinct kinomes that shed light on subtype-specific vulnerabilities such as receptor tyrosine kinases, including EGFR, in basal-like...

aacrjournals.org

The Evolutionary Forest of Pancreatic Cancer

Multiregion-sampled pancreatic cancers representing the full spectrum of clinical presentations reveal distinct genetic differences in pancreatic cancers with indolent features versus those with aggre...

aacrjournals.org

Nationwide Outcome after Pancreatoduodenectomy in Patients... : Annals of Surgery

is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as...

journals.lww.com

Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery

Dear Editor,

academic.oup.com

Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational ...

In this international retrospective cohort study from the Trans-Atlantic Pancreatic Surgery Consortium, the independent prognostic factors for overall surv

academic.oup.com

Improving Recurrence Prediction in Intrahepatic Cholangiocarcinoma: The Synergistic Impact of the FIB-4 Index and Tumor Burden Score on Post-hepatectomy Outcomes - Annals of Surgical Oncology

Background The prognostic role of the fibrosis-4 (FIB-4) index relative to intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study sought to characterize the impact of the ...

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Hierarchically Positioning Laparoscopic Microwave Ablation in the Therapeutic Span of Early Hepatocellular Carcinoma: A Real-Life Comparative Analysis - Annals of Surgical Oncology

Background Laparoscopic microwave ablation (LMWA) has yet to gain a specific place in treatment guidelines for early hepatocellular carcinoma (HCC). This study compared the outcomes of LMWA and trans-...

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Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody - Annals of Surgical Oncology

Background Gastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resec...

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The Duration of Immunotherapy for Mismatch Repair–Deficient Cancers | NEJM

An analysis of published studies suggests that a longer duration of immune checkpoint inhibitor therapy is associated with a higher incidence of complete response among patients with mismatch ...

nejm.org

Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

sciencedirect.com

Circulating Micro-RNA as a Predictive Biomarker for Radiation Response in Pancreas Cancer - Annals of Surgical Oncology

Annals of Surgical Oncology -

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Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort - Annals of Surgical Oncology

Background Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication m...

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