Centre for Synthetic Biology @TUDarmstadt

@synbio.bsky.social

Centre for Engineering-based Synthetic Biology @TUDarmstadt

Was könnte sich wohl hinter dieser⤵️Struktur verbergen? Heute, ist🧪Welttag des Labors🧫🥼wir gehen mit Rätsel Nr 4 unserer Serie „Alles beginnt mit Neugier“ an den🚀Start. Traut Euch+ratet mit – die Auflösung kommt morgen.🤫Kleiner Tipp, schaut doch mal hier vorbei ➡️ www.uni-marburg.de/de/fb17/robu...

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Here is answer no.5️⃣: The📷shows several mesocosms w/ genetically defined young 🌳oak clones. @loewe-tree-m.bsky.social uses them to investigate how bacterial communities influence fitness,health+development of trees and to understand the complex relationships betw.🌳🌲+their leaf-associated microbiome.

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FREITAG🎡 - und damit Tag5️⃣unserer Miniserie „Alles beginnt mit Neugier“ zum🧪Welttag des Labors🧫🥼+ die passenden Rate-Einstimmung zum🏖️Wochenende! Na, schon eine Vermutung? Lasst es uns wissen! Am MONTAG gibt es die Lösung.🤫Kleiner Tipp,👀doch mal hier vorbei➡️ www.uni-marburg.de/de/fb17/tree-m

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On to the final sprint: Today, on Day 6️⃣, of our mini-series “It All Starts with Curiosity” for 🧪World Laboratory Day🧫🥼 we’re sharing the penultimate image – give it a guess! We can’t wait to see your answers! A little hint for today: check out this ➡️link: www.pulmonary-infections.com

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Endspurt🏇🏼: Das vorletzte🖼️Bild unserer Miniserie „Alles beginnt mit Neugier“ zum🧪Welttag des Labors🧫🥼zum Mitraten. Heute an Tag6️⃣mit dem nächsten Rätsel. Wir sind schon sehr gespannt auf Eure Antworten! Ein kleiner Tipp: Wenn Ihr nicht weiterkommt, schaut doch mal hier vorbei ➡️ lnkd.in/dyuN8ATR

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Friday👌🏼—and that means Day5️⃣of our mini-series “It All Starts with Curiosity” for 🧪World Laboratory Day🧫🥼 & the perfect guessing game to kick off the weekend! So, any guesses yet? Let us know! We’ll reveal the answer💬on Monday.🤫Here’s a little hint—check this out➡️ www.uni-marburg.de/de/fb17/tree-m

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Die gemeinsame Veranstaltungsreihe des Zentrums für Gender Studies (ZGS) und des LOEWE-Schwerpunkts GenDem ist hybrid und kann somit auch ONLINE verfolgt werden. 💻 Alle Informationen finden Sie hier: ➡️ www.uni-marburg.de/de/genderzuk... #LOEWE #Hessen

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uni-marburg.de

ProLOEWE@proloewe.bsky.social · 4mo ago

The LOEWE-Research Cluster GenDem (led by @unimarburg.bsky.social) explores how anti-feminism, democracy+authoritarian tendencies are 🖇entangled. Join their ☀️Summer 2️⃣0️⃣2️⃣6️⃣ lecture series on “Anti/Feminism & Nationalism” in Marburg (thursdays, 6-8pm). Moreℹ️ ➡️ www.linkedin.com/feed/update/...

To celebrate🗺️World Lab Day🧪on April 23, we’re kicking off our mini-series “It All Starts with Curiosity” today. We’ll take you inside the world of LOEWE research—you’re warmly invited to join us. Feel free to share your answers in the comments section.✍🏽More ➡️ www.linkedin.com/posts/proloe...

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Zum🗺️Welttag des🧪Labors🧫🥼23.04. starten wir heute unsere Miniserie „Alles beginnt mit Neugier“. Wir zeigen Euch die Welt der LOEWE-Forschung – Ihr seid herzlich eingeladen mitzumachen. ✍🏽Eure Antworten gerne in die Kommentarzeile. Die Lösung gibt’s morgen früh, mehr ➡️ www.linkedin.com/posts/proloe...

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𝗠𝗼𝗿𝗴𝗲𝗻🥁𝗶𝘀𝘁 der 𝗧𝗮𝗴 𝗱𝗲𝗿 𝗙𝗿𝗮𝘂𝗲𝗻 & 𝗠ä𝗱𝗰𝗵𝗲𝗻 𝗶𝗻 𝗱𝗲𝗿 𝗪𝗶𝘀𝘀𝗲𝗻𝘀𝗰𝗵𝗮𝗳𝘁 + 𝘄𝗶𝗿 𝘄𝗼𝗹𝗹𝗲𝗻 𝗘𝘂𝗰𝗵 𝘀𝗰𝗵𝗼𝗻 𝗲𝗶𝗻 𝗯𝗶𝘀𝘀𝗰𝗵𝗲𝗻 𝗻𝗲𝘂𝗴𝗶𝗲𝗿𝗶𝗴 𝗺𝗮𝗰𝗵𝗲𝗻, 𝘄𝗲𝗻𝗻 𝗲𝘀 𝘄𝗶𝗲𝗱𝗲𝗿 𝗵𝗲𝗶ß𝘁 👉🏼𝗣𝗿𝗼𝗟𝗢𝗘𝗪𝗘 𝗽𝗿ä𝘀𝗲𝗻𝘁𝗶𝗲𝗿𝘁: 𝗩𝗶𝗲𝗹𝗲 𝗙𝗿𝗮𝘂𝗲𝗻, 𝗲𝗶𝗻𝗲 𝗠𝗶𝘀𝘀𝗶𝗼𝗻: 𝗟𝗢𝗘𝗪𝗘-𝗦𝗽𝗶𝘁𝘇𝗲𝗻𝗳𝗼𝗿𝘀𝗰𝗵𝘂𝗻𝗴 𝗮𝘂𝘀 𝗛𝗲𝘀𝘀𝗲𝗻👏🏽 – 𝗲𝗶𝗻𝗲 𝗔𝗸𝘁𝗶𝗼𝗻 𝘇𝘂𝗺 𝗶𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹𝗲𝗻 𝗧𝗮𝗴 𝗱𝗲𝗿 𝗠𝗮̈𝗱𝗰𝗵𝗲𝗻+𝗙𝗿𝗮𝘂𝗲𝗻,𝟭𝟭. FEB 𝟮𝟬𝟮𝟲!

How does charge and pore size shape polymer growth? The groups of Nico Bruns and Annette Andrieu-Brunsen @tuda.bsky.social show how enzyme-catalyzed polymerization inside mesoporous silica can be tuned and even visualized opening new paths for functional nanomaterials. pubs.acs.org/doi/abs/10.1...

Varying Monomer Charge in SI-bioATRP Polymer Grafting from Mesoporous Silica

Polymer functionalization of mesoporous materials is crucial for a range of technologies including separation and sensing. In this study, we investigate the influence of monomer charge on enzyme-catalyzed polymerizations in mesoporous silica particles. Specifically, we copolymerize various charged monomers, such as potassium 3-sulfopropyl methacrylate (KSPMA), [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC), 2-hydroxyethyl methacrylate phosphate (MEP), and 2-(dimethylamino)ethyl methacrylate (DMAEMA), with the positively charged fluorescent comonomer rhodamine-hydroxyethyl methacrylate (RhoB-HEMA), using enzyme-catalyzed surface-initiated atom transfer radical polymerization (SI-bioATRP). The polymerizations were performed in mesoporous spherical silica particles with average pore diameters of 23, 21, 17, and 12 nm using hemoglobin (Hb) as the catalyst. By adjusting the ratio of the fluorescent comonomer RhoB-HEMA to the charged monomers, the amount of the fluorescent comonomer in the polymers can be varied. Size-restricted accessibility of hemoglobin and small molecules, such as monomers to mesopores, especially when the pore neck diameter was smaller than the size of the protein, led to polymer formation mostly in the outer regions of the particles. Larger mesopores led to a homogeneous distribution of copolymers throughout the particles and to a higher overall polymer content within the mesoporous structures. These findings provide insights into the possibilities of functionalizing silica mesopores with polyelectrolytes via enzymatic SI-bioATRP, while the fluorescent comonomer enabled direct visualization of the copolymers by fluorescence microscopy. We anticipate that this approach will further advance the field of polymerization in confined nanoporous environments.

pubs.acs.org

On #WorldCancerDay, proud that MultiDrug-TDM helps drive innovation for better quality of life for pediatric cancer patients 🎗️

ProLOEWE@proloewe.bsky.social · 6mo ago

FEB 4 is🌎🎗️ #WorldCancerDay. Cancer affects millions, bringing physical and emotional challenges. The LOEWE Center @loewe-fci.bsky.social and LOEWE Research Clusters CARISMa + MultiDrug-TDM advance🆕therapies and early detection – driving targeted, effective🩺💊treatments for a better quality of life.

How do cells keep their recycling system running? A research collaboration led by @tuda.bsky.social+headed by Dr. Oliver Rauh uncovered how the protein TMEM175 prevents Lysosome hyperacidity+how dysfunctions damage neurons and can be linked to Parkinson’s. The results provide a basis for🆕therapies.

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