How do PTMs affect the binding of small molecule drugs to their target proteins? Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline". Blog post: www.science.org/content/blog... Paper: www.nature.com/articles/s41... (1/4)

Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...

nature.com

Nextstrain #ANDV trees updated with a few improvements: - 2 outbreaks marked - host scientific/common name added - province now visible on map - date colouring added Here's a quick tour of how to change colours, geography & names! Links to trees here (scroll down): nextstrain.org/groups/hodcr...

Super quick sequencing from the Swiss team!! I found some time to do a quick phylo analysis posted here: virological.org/t/complete-s... #hantavirus #ANDV

Complete sequence of Orthohantavirus andesense virus: Swiss resident 2026

Thank you for sharing! Had some free time and had a go at making some segment trees. Brief methods: Downloaded all taxid 1980456 nucleotide sequences Separated by segment and made some preliminary ...

virological.org

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

science.org

🦠The future of pathogen forecasting needs rigorous benchmarks and domain-specific modeling, not only bigger PLMs. EVEREST is a step in that direction. 🔗Paper: biorxiv.org/content/10.1... 💻Code + data: github.com/debbiemarksl... 12/12

Variant effect prediction with reliability estimation across priority viruses

Viruses pose a significant threat to global health due to their rapid evolution, adaptability, and increasing potential for cross-species transmission. While advances in machine learning and the growi...

biorxiv.org

I finally know why the cap was designed that way.....

Kraemer et al. use machine learning to model epidemics more efficiently. Their work shows faster forecasting, better handling of incomplete data, and more accurate infection estimates, pointing to improved global health decision making. www.nature.com/articles/s41...

Artificial intelligence for modelling infectious disease epidemics - Nature

This Perspective considers the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science.

nature.com

Interesting bioRxiv preprint by a team around Charles Craik, Adam Renslo and @theottlab.bsky.social. Inhibitors for Mpro of coronaviruses based on a dihydrouracil chemotype and a propargyl amide warhead as reactive group to engage the catalytic cysteine. #chemsky #ChemBio www.biorxiv.org/cont...

Thrilled to share our latest work identifying that #SARSCoV2 #Omicron variants harboring an L260F mutation in NSP6 have enhanced replication and pathogenesis. A not so brief thread 🧵