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Taylor Head, PhD

@taylorhead.bsky.social

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Taylor Head, PhD@taylorhead.bsky.social · 4mo ago

Excited to present a poster at #bog26 this evening starting at 7:30pm! Come by poster #108 to learn about some motivating and preliminary work on a novel method to fine-map causal isoforms in TWAS leveraging tissue-specific long-read RNA-seq evidence.

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Arjun Bhattacharya@arjunbhattac.bsky.social · 5mo ago

Another preprint from our group @mdanderson.bsky.social led by talented postdoc @seantbres.bsky.social! Joint with @jonhuang.bsky.social, exploring the intersection of environmental toxins, maternal/fetal health, and placental txomics. Tweet thread below!

Sean Bresnahan@seantbres.bsky.social · 5mo ago

🧬Another new preprint with @jonhuang.bsky.social @uhmanoa.bsky.social & @arjunbhattac.bsky.social @mdanderson.bsky.social ! We used variation in how PFAS cross the placenta to dissect the transcriptional architecture of effects on birthweight & gestational age🧵 www.biorxiv.org/content/10.6...

Transplacental transfer efficiency reveals dose-dependent network architectures linking PFAS exposure to birth outcomes. Per- and polyfluoroalkyl substances (PFAS) exhibit varied transplacental transfer efficiencies (TPTE), quantified as the ratio of fetal cord blood to maternal blood concentrations. PFOS shows low TPTE with limited fetal exposure, while PFBS demonstrates high TPTE with substantial transfer to the fetus. PFAS concentrations were measured in maternal blood and fetal cord blood alongside placental transcriptomics, gestational age at delivery, and birth weight. Placental transcripts mediating PFAS effects on birth weight were characterized by four network properties: mediator count (number of significant mediating transcripts), co-expression strength (|kME|, representing correlation with module eigengene and shown as network connectivity), network centrality (hub positioning within the network), and compartmentalization (spatial clustering of maternal versus fetal mediators). Birth weight exhibited coordinated TPTE-dependent responses across these network metrics, with high-TPTE compounds engaging more numerous, strongly co-expressed mediators occupying central network positions with distinct maternal-fetal compartmentalization. In contrast, gestational age showed minimal coordinated network reorganization in response to TPTE variation, indicating distinct molecular architectures underlying PFAS effects on these different outcomes.